912641-16-8Relevant academic research and scientific papers
Synthesis and monoamine transporter affinity of 3α-arylmethoxy-3β-arylnortropanes
Kaur, Harneet,Izenwasser, Sari,Verma, Abha,Wade, Dean,Housman, Amy,Stevens, Edwin D.,Mobley, David L.,Trudell, Mark L.
supporting information; experimental part, p. 6865 - 6868 (2010/06/16)
A series of 3-arylnortrop-2-enes and 3α-arylmethoxy-3β-arylnortropanes were synthesized and evaluated for binding affinity at monoamine transporters. The 3-(3,4-dichlorophenyl)nortrop-2-ene (6e) exhibited high affinity for the SERT (Ki = 0.3 nM
Modulation of selective serotonin reuptake inhibitor and 5-HT1A antagonist activity in 8-aza-bicyclo[3.2.1]octane derivatives of 2,3-dihydro-1,4-benzodioxane
Gilbert, Adam M.,Stack, Gary P.,Nilakantan, Ramaswamy,Kodah, Jason,Tran, Megan,Scerni, Rosemary,Shi, Xiaojie,Smith, Deborah L.,Andree, Terrance H.
, p. 515 - 518 (2007/10/03)
2,3-Dihydro-1,4-benzodioxanes with aryl 8-aza-bicyclo[3.2.1]oct-3-ene attachments 2 produce compounds with potent 5-HT-T affinity, and weak 5-HT 1A affinity and α1 affinity. This compares with 2,3-dihydro-1,4-benzodioxanes containing 8-aza-bicyclo[3.2.1] octan-3-ol attachments 4 which possess potent 5-HT1A affinity, moderate to good selectivity over α1 and little 5-HT-T affinity. A 3-benzothiophene analogue of 4 (30) was synthesized which possesses potent 5-HT1A affinity and especially good selectivity over both α1 and 5-HT-T.
Novel aryloxy-8-azabicyclo[3.2.1]oct-3-enes with 5-HT transporter and 5-HT1A affinity
Gilbert, Adam M.,Coleman, Thomas,Kodah, Jason,Mewshaw, Richard E.,Scerni, Rosemary,Schechter, Lee E.,Smith, Deborah L.,Andree, Terrance H.
, p. 5281 - 5284 (2007/10/03)
Joining aryl 8-azabicyclo[3.2.1]oct-3-enes with aryloxyethanes and aryloxypropanes produces novel series of compounds 11 and 12 with potent 5-HT-T affinity and moderately potent 5-HT1A affinity. Moreover, several of these compounds possess func
Aryl-8-azabicyclo [3.2.1] octanes for the treatment of depression
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, (2008/06/13)
The present invention includes compounds of formula I wherein A, X, n, Ar1, and Ar2 are defined as set forth herein. These compounds may be used to treat depression. The invention also includes formulations containing these compounds, and methods for making and using compounds of this invention.
8-azabicyclo[3.2.1.]oct-2-ene derivatives, their preparation and use
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, (2008/06/13)
PCT No. PCT/EP96/04449 Sec. 371 Date May 18, 1998 Sec. 102(e) Date May 18, 1998 PCT Filed Oct. 11, 1996 PCT Pub. No. WO97/13770 PCT Pub. Date Apr. 17, 1997A compound having the formula, or any of its enantiomers or any mixture thereof, or a pharmaceutical
