91265-75-7Relevant articles and documents
Synthesis and pharmacological properties of morphine congeners having pendant crown ether as an opioid receptor probe
Fujii,Togame,Kanematsu
, p. 4439 - 4442 (1986)
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An improved synthesis of noroxymorphone
Ninan,Sainsbury
, p. 6709 - 6716 (2007/10/02)
A brief synthesis of noroxymorphone is described which involves the oxidation of 3-O-(t)butyldimethylsilylmorphine by manganese dioxide. The initial product is the corresponding morphinone which is further oxidised to the 14-hydroxymorphinone. After hydrogenation the 7,8-dihydro-14-hydroxymorphinone is acetylated and N-demethylation of the 14-O-acetylated product is achieved using vinyl chloroformate as the reagent. The overall yield from morphine is 40-45%.