91266-58-9Relevant academic research and scientific papers
Organo-tin compounds having anti-tumour activity and anti-tumour compositions
-
, (2008/06/13)
The invention relates to anti-tumor compositions containing as an active ingredient one or more compounds of the formula wherein X and Y are each H, OH, halogen or alkyl; and Z is halogen, amino, alkoxy, acyloxy, sulphonic acid or alkyl. A number of these compounds are novel compounds.
Organotin Biocides. Part 11. Triphenyltin Benzoates: Electronic versus Steric Control of Structure
Molloy, Kieran C.,Blunden, Stephen J.,Hill, Robin
, p. 1259 - 1266 (2007/10/02)
Twenty four triphenyltin derivatives of substituted benzoic acids have been synthesised.On the basis of i.r., (119)Sn n.m.r. and Moessbauer spectroscopic data, structures have been assigned to these compounds as either tetrahedral monomers or trans-SnR3O2
Intramolecularly formed pentacoordinated structures of triphenyltin esters of salicylic acid, o-anisic acid, and p-methylthiobenzoic acid
Vollano, Jean F.,Day, Roberta O.,Rau, Denise N.,Chandrasekhar,Holmes, Robert R.
, p. 3153 - 3160 (2008/10/08)
Triphenyltin esters were formed by the reaction of bis(triphenyltin) oxide with salicylic acid, o-anisic acid, and p-methylthiobenzoic acid, 6-8, respectively. X-ray analysis revealed pentacoordinated structures containing Ph3Sn coordinated to the carboxylate group for 7 and 8. The structural distortion for each is a displacement from the tetrahedron toward a trigonal bipyramid. For 6, the structure contains an intramolecular oxygen atom interaction, in addition to hydrogen-bonding effects, with a resultant geometry close to tetrahedral. Infrared data confirm that carboxylate coordination occurs in solution. Factors influencing the appearance of the discrete five-coordinated form 6-8 relative to five-coordinated tin in a chain arrangement for related derivatives is discussed. For 6, the monoclinic space group P21/c (Z = 4) was obtained with a = 13.318 (6) ?, b = 12.113 (2) ?, c = 14.590 (4) ?, and β = 116.47 (3)°. Refinement gave R = 0.022 and Rw = 0.032. 7 crystallizes in the triclinic space group P1 (Z = 2) with a = 10.632 (2) ?, b = 11.452 (2) ?, c = 11.719 (2) ?, α = 62.86 (2)°, β = 71.95 (2)°, and γ = 62.31 (2)°. Refinement gave R = 0.024 and Rw = 0.041. For 8, the triclinic space group P1 resulted with a = 8.814 (1) ?, b = 9.816 (1) ?, c = 14.430 (3) ?, α = 89.39 (1)°, β = 80.19 (1)°, and γ = 68.89 (1)°. Refinement gave R = 0.025 and Rw = 0.040.
