91273-58-4

Usage

Uses

Used in Pharmaceutical Industry:
3-BENZYLOXY-1-BROMO-2-METHYLPROPANE is used as a key intermediate in the synthesis of various pharmaceutical compounds due to its reactivity and ability to participate in a range of chemical reactions, contributing to the development of new drugs and medications.
Used in Fragrance and Flavoring Industry:
3-BENZYLOXY-1-BROMO-2-METHYLPROPANE is used as a precursor in the production of fragrances and flavoring agents, leveraging its chemical properties to create a variety of scents and tastes for consumer products.
Used in Organic Synthesis:
3-BENZYLOXY-1-BROMO-2-METHYLPROPANE is employed as a versatile building block in organic synthesis, enabling the creation of a diverse array of chemical compounds for various applications across different industries.
It is crucial to handle 3-BENZYLOXY-1-BROMO-2-METHYLPROPANE with care and adhere to safety protocols, as it is considered hazardous to human health and the environment.

Upstream product

• 63930-46-1 3-(benzyloxy)-2-methylpropan-1-ol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 64809-18-3 4-benzyloxy-3-methylbutyronitrile 
• 1073165-11-3 3-benzyloxy-2-methyl-1-propylmagnesium bromide 

Relevant academic research and scientific papers

Positron emission tomography to elucidate pharmacokinetic differences of regioisomeric retinoid x receptor agonists

RXR partial agonist NEt-4IB (2a, 6-[ethyl-(4-isobutoxy-3-isopropylphenyl)amino]pyridine-3-carboxylic acid: EC50 = 169 nM, Emax = 55%) showed a blood concentration higher than its Emax after single oral administration at 30 mg/kg to mice, and repeated oral administration at 10 mg/kg/day to KK-Ay mice afforded antitype 2 diabetes activity without the side effects caused by RXR full agonists. However, RXR full agonist NEt-3IB (1a), in which the isobutoxy and isopropyl groups of 2a are interchanged, gave a much lower blood concentration than 2a. Here we used positron emission tomography (PET) with tracers [11C]1a, [11C]2a and fluorinated derivatives [18F]1b, [18F]2b, which have longer half-lives, to examine the reason why 1a and 2a exhibited significantly different blood concentrations. As a result, the reason for the high blood concentration of 2a after oral administration was found to be linked to higher intestinal absorbability together with lower biliary excretion, compared with 1a.

ACYLOXYKETONE SUBSTITUTED IMINO AND AMINO ACIDS

Acyloxyketone substituted imino and amino acids of the formula STR1 are disclosed. These compounds are useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.

Synthesis of 2,6,10-trimethyl-undecan-1-ol

A synthesis of 2,6,10-trimethyl-undecan-1-ol, an intermediate for producing vitamin E, from methacrolein, crotonaldehyde, β-hydroxy-isobutyric acid including intermediates in this synthesis.