912773-21-8

Basic information

• Product Name: 5-BROMO-2-CHLOROPYRAZINE
• Synonyms: 5-BROMO-2-CHLOROPYRAZINE;2-BROMO-5-CHLOROPYRAZINE;2-Bromo-5-chloro-1,4-diazine;2-Chloro-5-bromopyrazine
• CAS NO: 912773-21-8
• Molecular Formula: C₄H₂BrClN₂
• Molecular Weight: 193.43
• Product Categories: Building Blocks;Pyrazine
• Mol File: 912773-21-8.mol

Chemical Properties

• Boiling Point: 208℃
• Flash Point: 80℃
• Appearance: /
• Density: 1.859
• Vapor Pressure: 0.313mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -4.53±0.10(Predicted)
• CAS DataBase Reference: 5-BROMO-2-CHLOROPYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-CHLOROPYRAZINE(912773-21-8)
• EPA Substance Registry System: 5-BROMO-2-CHLOROPYRAZINE(912773-21-8)

Safety Data

• Hazardous Substances Data: 912773-21-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-BROMO-2-CHLOROPYRAZINE is used as a synthetic intermediate for the development of various pharmaceuticals. Its unique structure and properties make it a valuable component in the creation of new drugs and medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 5-BROMO-2-CHLOROPYRAZINE is utilized as an intermediate in the synthesis of agrochemicals. Its role in this industry is crucial for the development of effective and innovative products for agricultural applications.
Used in Organic Compounds Synthesis:
5-BROMO-2-CHLOROPYRAZINE is employed as a key intermediate in the synthesis of other organic compounds. Its reactivity and structural features contribute to the formation of a wide range of organic molecules with diverse applications.
Used in Research and Laboratory Applications:
5-BROMO-2-CHLOROPYRAZINE is also utilized in research and laboratory settings. Its properties make it suitable for various experimental procedures and studies, contributing to the advancement of scientific knowledge and the development of new technologies.

InChI:InChI=1/C4H2BrClN2/c5-3-1-8-4(6)2-7-3/h1-2H

Upstream product

• 374063-92-0 2-hydroxy-5-bromopyrazine 

Downstream Products

• 955050-08-5 4-(5-bromopyrazin-2-yl)morpholine 

Relevant articles and documents

Favipiravir intermediate and synthesis method of favipiravir

The invention discloses a favipiravir intermediate and a synthesis method of favipiravir. The synthesis method comprises the following steps: taking 2,5-dihalopyrazine as an initial raw material, reacting 2,5-dihalopyrazine with formamide under the action of an oxide and a catalyst to generate 6-halo-3-chloro-2-amide pyrazine; carrying out a reaction on 6-halo-3-chloro-2-amide pyrazine under the action of a dehydration chlorinating agent and an acid-binding agent to generate a favipiravir intermediate 3,6-dichloro-3-cyanopyrazine; carrying out an aromatic ring fluorination reaction on the obtained favipiravir intermediate and potassium fluoride in dimethyl sulfoxide to generate 3,6-difluoro-3-cyanopyrazine; adding the 3,6-difluoro-3-cyanopyrazine into a water solution containing sodium acetate, and carrying out hydrolysis to obtain 6-fluoro-3-hydroxyl-2-cyanopyrazine; and finally, carrying out a cyano hydrolysis reaction to obtain favipiravir. A mixture of 2,5-dichloropyrazine and 2-chloro-5-bromopyrazine are used as raw materials to synthesize the favipiravir intermediate, the raw material cost is remarkably reduced, and the provided synthesis method has the technical advantages of high yield and low cost.