374063-92-0

Basic information

• Product Name: 2-Bromo-5-hydroxypyrazine
• Synonyms: 5-BROMO-2-PYRAZINOL;5-BROMO-2-HYDROXYPYRAZINE;5-BROMO-2-HYDROXYPYRAZINE,5-BROMO-2-PYRAZINOL;5-bromopyrazin-2-ol;5-bromopyrazin-2-o;2(1H)-Pyrazinone, 5-bromo- 2-Bromo-5-hydroxypyrazine;5-Bromopyrazin-2(1H)-one;2-hydroxy-5-bromopyrazine
• CAS NO: 374063-92-0
• Molecular Formula: C₄H₃BrN₂O
• Molecular Weight: 174.98
• Product Categories: Piperazine series;Building Blocks;Pyrazine;Building Blocks/Intermediates
• Mol File: 374063-92-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 115-119°C
• Boiling Point: 444.001 °C at 760 mmHg
• Flash Point: 222.324 °C
• Appearance: White to light brown/Crystalline Powder
• Density: 1.934 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.625
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 10.02±0.40(Predicted)
• CAS DataBase Reference: 2-Bromo-5-hydroxypyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-hydroxypyrazine(374063-92-0)
• EPA Substance Registry System: 2-Bromo-5-hydroxypyrazine(374063-92-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 1
• Hazardous Substances Data: 374063-92-0(Hazardous Substances Data)

Usage

Uses

5-bromo-1H-pyrazin-2-one is a useful research chemical.

InChI:InChI=1/C4H3BrN2O/c5-3-1-7-4(8)2-6-3/h1-2H,(H,7,8)

Upstream product

• 6270-63-9 pyrazin-2-ol 
• 59489-71-3 5-amino-2-bromopyrazine 

Downstream Products

• 19745-07-4 2,5-dichloropyrazine 
• 912773-21-8 2-bromo-5-chloro-pyrazine 
• 356783-16-9 3,6-dichloropyrazine-2-carbonitrile 
• 1208084-90-5 2-(benzyloxy)-5-bromopyrazine 
• 1287686-14-9 2-bromo-5-(1-(4-(trifluoromethyl)benzyl)azetidin-3-yloxy)pyrazine 
• 622387-30-8 1-benzyl 4-methyl 4-{[4-(5-butylpyridin-2-yl)piperidin-1-yl]sulfonyl}piperidine-1,4-dicarboxylate 
• 1209459-10-8 2-bromo-5-fluoropyrazine 

Relevant articles and documents

Favipiravir intermediate and synthesis method of favipiravir

The invention discloses a favipiravir intermediate and a synthesis method of favipiravir. The synthesis method comprises the following steps: taking 2,5-dihalopyrazine as an initial raw material, reacting 2,5-dihalopyrazine with formamide under the action of an oxide and a catalyst to generate 6-halo-3-chloro-2-amide pyrazine; carrying out a reaction on 6-halo-3-chloro-2-amide pyrazine under the action of a dehydration chlorinating agent and an acid-binding agent to generate a favipiravir intermediate 3,6-dichloro-3-cyanopyrazine; carrying out an aromatic ring fluorination reaction on the obtained favipiravir intermediate and potassium fluoride in dimethyl sulfoxide to generate 3,6-difluoro-3-cyanopyrazine; adding the 3,6-difluoro-3-cyanopyrazine into a water solution containing sodium acetate, and carrying out hydrolysis to obtain 6-fluoro-3-hydroxyl-2-cyanopyrazine; and finally, carrying out a cyano hydrolysis reaction to obtain favipiravir. A mixture of 2,5-dichloropyrazine and 2-chloro-5-bromopyrazine are used as raw materials to synthesize the favipiravir intermediate, the raw material cost is remarkably reduced, and the provided synthesis method has the technical advantages of high yield and low cost.

Alpha substituted carboxylic acids

Alpha substituted carboxylic acids of formula (I):

Studies on pyrazines, Part 39.1 Synthesis and acidic hydrolysis of 2-hydroxy-5-methoxypyrazine

2-Hydroxy-5-methoxypyrazine was synthesised in a three-step reaction sequence starting from aminopyrazine. The product was extensively destroyed on acidic workup without forming 2,5-dihydroxypyrazine.