912816-63-8

Basic information

• Product Name: 4-[3-N-(tert-butyloxycarbonyl)propyloxy]-5-methoxybenzaldehyde
• Synonyms: 4-[3-N-(tert-butyloxycarbonyl)propyloxy]-5-methoxybenzaldehyde
• CAS NO: 912816-63-8
• Molecular Weight: 309.362
• Mol File: 912816-63-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[3-N-(tert-butyloxycarbonyl)propyloxy]-5-methoxybenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[3-N-(tert-butyloxycarbonyl)propyloxy]-5-methoxybenzaldehyde(912816-63-8)
• EPA Substance Registry System: 4-[3-N-(tert-butyloxycarbonyl)propyloxy]-5-methoxybenzaldehyde(912816-63-8)

Safety Data

• Hazardous Substances Data: 912816-63-8(Hazardous Substances Data)

Upstream product

• 58885-58-8 N-tert-butoxycarbonyl-3-aminopropanol 
• 121-33-5 vanillin 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 912816-65-0 5-(4-methylpiperazin-1-yl)-2-[2'-(4-{3-aminopropyloxy}-3-methoxyphenyl)-5'-benzimidazolyl]benzimidazole 
• 912816-64-9 (3-{2-methoxy-4-[5-(4-methyl-piperazin-1-yl)-1H,1'H-[2,5']bibenzoimidazolyl-2'-yl]-phenoxy}-propyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Triple helix stabilization by covalently linked DNA-bisbenzimidazole conjugate synthesized by maleimide-thiol coupling chemistry

Tethering of BBZPNH2, an analogue of the Hoechst 33258, with a 14 nucleotide long DNA sequence with the help of succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC), a heterobifunctional crosslinking reagent, using DMF/ water as solvent yields a conjugate which effectively stabilizes the triple helix. The above conjugate was hybridized with 26 bp long double stranded (ds) DNA having 14 bp long polypurine-polypyrimidine stretch to form a pyrimidine motif triple helix. The above conjugate increases the thermal stability of both the transitions, that is, triple helix to double helix by 12 °C and double helix to single strand transition by 16 °C for the triple helix formed with conjugated TFO over the triple helix made from non-conjugated TFO. Fluorescence and circular dichroism spectra recorded at different temperatures confirm the presence of minor groove binding bisbenzimidazole in the AT-rich minor groove of dsDNA even after the major groove bound TFO separates out.