91282-39-2Relevant academic research and scientific papers
Expanding the chemical space of aryloxy-naphthoquinones as potential anti-Chagasic agents: synthesis and trypanosomicidal activity
Aranda, Mario,Becerra, Nohemí A.,Cantero, Jorge,Castillo-Velazquez, Uziel,Chacón-Vargas, Fabiola,Espinosa-Bustos, Christian,Moreno-Rodríguez, Adriana,Nogueda, Benjamín,Paulino, Margot,Rivera, Gildardo,Rodríguez, Ana F. Elizondo,Salas, Cristian O.,Toledo, Sofía,Vázquez, Karina
, p. 2256 - 2265 (2021/10/27)
In continuation our effort to research the chemical space of aryloxy-naphthoquinones as potential anti-Chagas agents, we synthesized nine derivatives and these compounds were evaluated in vitro against the epimastigote and trypomastigote forms of Mexican
Water-promoted unprecedented chemoselective nucleophilic substitution reactions of 1,4-quinones with oxygen nucleophiles in aqueous micelles
Tandon, Vishnu K.,Maurya, Hardesh K.
experimental part, p. 3843 - 3847 (2010/08/20)
Unique nucleophilic substitution and addition reactions of nitrogen and sulfur nucleophiles with 1,4-quinones in aqueous suspension with amines and thiols have recently been demonstrated by us.2 However, the reactivity of oxygen nucleophiles toward nucleophilic substitution compared to nitrogen and sulfur nucleophiles 'on water' is not facile. An unprecedented economical, green methodology approach using ordinary laundry detergent (LD; washing powder, 0.5 mol %, reusable)/SDS as surfactant 'in water' for nucleophilic substitution by oxygen nucleophiles in 1,4-quinones in excellent yields has been demonstrated.
Cesium carbonate-mediated reaction of dichloronaphthoquinone derivatives with O-nucleophiles
Lee, Do-Min,Ko, Ju Hong,Lee, Kee-In
, p. 741 - 746 (2008/02/09)
A cesium carbonate-mediated reaction of 2,3-dichloronaphthoquinone, 6,7-dichloro-5,8-quinolinedione, and -isoquinolinedione with oxygen nucleophiles has been described.
Thiazolidine compounds, their preparation and their therapeutic uses
-
, (2008/06/13)
Compounds of formula (I): (in which: R1 is alkyl; R2 and R3 are each alkyl or alkoxy, or R2 and R3 together form an optionally substituted benzene ring, and, when R2 and R3 together form said benzene ring, R1 is hydrogen, halogen or alkyl; R4 and R5 are hydrogen, or R4 and R5 together represent a single carbon-carbon bond; Y1 and Y2 are each hydrogen, alkyl, acyl, or optionally substituted benzoyl, naphthoyl, pyridine-carbonyl or quinolinecarbonyl; W is a single bond or alkylene; and Z is hydrogen or a cation) have valuable therapeutic and prophylactic activities, including anti-diabetic activities.
