91284-00-3Relevant academic research and scientific papers
Biomimetic oxidation of denaverine hydrochloride
Smolinka, Kai,G?ber, Berthold
, p. 679 - 683 (2007/10/03)
The behavior of denaverine (1) in various chemical model systems based on metalloporphyrins as catalysts was investigated to determine the possible oxidative metabolism. The resulting derivatives were compared to a biological model system and in vivo metabolism in rat and human.
Biotransformation of denaverine hydrochloride (Spasmalgan) in the rat
Goeber, B.,Lisowski, Hannelore,Friese, Dagmar,Franke, P.
, p. 493 - 495 (2007/10/02)
After oral application of denaverine hydrochloride to rats (200-250 mg/kg) 12 metabolites have been detected in urine.Besides the unchanged drug, 8 metabolites were identified by MS as 2,2-diphenyl-(2-dimethylaminoethyl)acetate (3), diphenylacetic (5) and benzilic acid (6), methyl- and ethyl acetate (7,11), methylbenzilate (10),N-demethyl-1 (12) and 3,3-diphenylmorpholin-2-one (13). 6 and metabonate 13 represent the main metabolic products.Compounds 7 and 11 indicate the metabolic pathway about an alkoxybenzilic acid (4).Phenols resp. conjugates were not detected.
