91290-08-3Relevant academic research and scientific papers
Ar(alk)ylsulfonyl ethyl groups as phosphorus-protecting functions
Claesen, C. A. A.,Segers, R. P. A. M.,Tesser, G. I.
, p. 119 - 122 (2007/10/02)
Various 2-ethanols were prepared and subsequently converted into the corresponding phosphorodichloridites in almost quantitative yield via a convenient synthetic route.The versatility of the method, which obviates the necessity of a distillation step, is demonstrated by the preparation of other (Ar(alk)yl phosphorodichloridites, including the unstable benzyl phosphorodichloridite.
USE OF 2-METHYLSULFONYLETHYL AS A PHOSPHOROUS PROTECTING GROUP IN OLIGONUCLEOTIDE SYNTHESIS VIA A PHOSPHITE TRIESTER APPROACH
Claesen, C.,Tesser, G. I.,Dreef, C. E.,Marugg, J. E.,Marel, G. A. van der,Boom, J. H. van
, p. 1307 - 1310 (2007/10/02)
2-Methylsulfonylethoxy dichlorophosphine has been converted into the mono-N-morpholino derivative and applied for the preparation of 5'-O,N-protected d-nucleoside-3'-phosphoramidites.The latter intermediates could be used in the presence of 1-hydroxybenzotriazole for the formation of 3'-5'-phosphotriester linkages.The MSE protecting group can be removed selectively and fast under mild basic conditions.
