912923-82-1Relevant academic research and scientific papers
Pyridine amides as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1
Wang, Haixia,Ruan, Zheming,Li, James J.,Simpkins, Ligaya M.,Smirk, Rebecca A.,Wu, Shung C.,Hutchins, Robert D.,Nirschl, David S.,Van Kirk, Katy,Cooper, Christopher B.,Sutton, James C.,Ma, Zhengping,Golla, Rajasree,Seethala, Ramakrishna,Salyan, Mary Ellen K.,Nayeem, Akbar,Krystek Jr., Stanley R.,Sheriff, Steven,Camac, Daniel M.,Morin, Paul E.,Carpenter, Brian,Robl, Jeffrey A.,Zahler, Robert,Gordon, David A.,Hamann, Lawrence G.
scheme or table, p. 3168 - 3172 (2009/04/11)
Several series of pyridine amides were identified as selective and potent 11β-HSD1 inhibitors. The most potent inhibitors feature 2,6- or 3,5-disubstitution on the pyridine core. Various linkers (CH2SO2, CH2S, CH2/su
Inhibitors of 11-beta hydroxysteroid dehydrogenase type I
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Page/Page column 28, (2010/11/24)
Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds have the structure: or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein G, L, Q, Z, R6, R7, and R8 are defined herein.
