912941-34-5Relevant academic research and scientific papers
Synthesis of lipid A monosaccharide analogues containing acidic amino acid: Exploring the structural basis for the endotoxic and antagonistic activities
Akamatsu, Masao,Fujimoto, Yukari,Kataoka, Mikayo,Suda, Yasuo,Kusumoto, Shoichi,Fukase, Koichi
, p. 6759 - 6777 (2007/10/03)
For elucidation of the structural and conformational requirements on the endotoxic and antagonistic activity of lipid A derivatives, we designed and synthesized lipid A analogues containing acidic amino acid residues in place of the non-reducing end phosp
Synthesis and biological activities of biscarboxymethyl lipid A analogues
Kataoka, Mikayo,Hashimoto, Masaya,Suda, Yasuo,Kusumoto, Shoichi,Fukase, Koichi
, p. 395 - 415 (2008/02/13)
Biscarboxymethyl analogues of Escherichia coli lipid A and the biosynthetic precursor-type lipid A were synthesized in order to elucidate the role of the acidic functional groups in the biological activity. Both analogues showed respective activities simi
