91298-66-7

Basic information

• Product Name: (S)-3-Aminohexanoic acid
• Synonyms: (S)-3-Aminohexanoic acid;[S,(+)]-3-Aminohexanoic acid;(3S)-(+)-3-Aminohexanoic acid
• CAS NO: 91298-66-7
• Molecular Formula: C6H13NO2
• Molecular Weight: 131.17
• Mol File: 91298-66-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-3-Aminohexanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-Aminohexanoic acid(91298-66-7)
• EPA Substance Registry System: (S)-3-Aminohexanoic acid(91298-66-7)

Safety Data

• Hazardous Substances Data: 91298-66-7(Hazardous Substances Data)

Usage

General Description

(S)-3-Aminohexanoic acid, also known as (S)-lysine, is an organic compound with the chemical formula C6H13NO2. It is an essential amino acid, meaning it cannot be synthesized by the body and must be obtained from dietary sources. (S)-3-Aminohexanoic acid is an important component of proteins and plays a crucial role in the synthesis of collagen, enzymes, and hormones. It also has a role in the maintenance of healthy bones, muscle growth, and the production of energy. This chemical compound is commonly found in foods such as meat, poultry, fish, dairy products, and certain grains. It is also available as a dietary supplement and is used in the pharmaceutical and cosmetic industries for its various health and skin benefits.

Upstream product

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Downstream Products

• 95513-34-1 (S)-(-)-benzyl 2-hydroxypentanoate 

Relevant articles and documents

Improving Catalytic Activity and Reversing Enantio-Specificity of ω-Transaminase by Semi-Rational Engineering en Route to Chiral Bulky β-Amino Esters

The application of wild-type ω-transaminase was limited by steric hindrance towards bulky substrates, therefore improvement of the catalytic efficiency and stereoselectivity toward substrates with two bulky substituent adjacent to the carbonyl is of general interest. In this study, according to the double substrate binding pocket theory, a (S)-selective ω-transaminase from the Burkholderia vietnamiensis G4, which showed puny catalytic activity toward the β-keto esters with small steric hindrance, was engineered to accept bulky β-keto esters, which were not accessible by any wild-type enzyme. A few desired variants were obtained that exhibited activity toward bulky β-keto esters. Furthermore, a substrate-dependent shift in enantio-preference of HBV variant towards β-keto esters with linear or branched aliphatic substituents was observed. The best variant was applied to the asymmetric synthesis of aliphatic β-amino acids at semi-preparative scale with high yield and enantioselectivity. This study will improve the general understanding and inspire further engineering work for reversing enantio-specificity of ω-transaminases.

Enantioselektive Synthese von β-Aminosaeuren - TMS-SAMP als chirales Ammoniak-Aequivalent in der azaanalogen Michael-Addition an α,β-ungesaettigte Ester

Stichworte: Aminosaeuren * Asymmetrische Synthesen * Chirale Hilfsstoffe * Michael-Additionen