59663-70-6

Usage

InChI:InChI=1/C8H17NO2/c1-3-5-7(9)6-8(10)11-4-2/h7H,3-6,9H2,1-2H3

Upstream product

• 613-94-5 benzoic acid hydrazide 
• 3249-68-1 ethyl butyroyl acetate 
• 1068-57-1 acetic acid hydrazide 
• 1071-46-1 hydrogen ethyl malonate 
• 123-72-8 butyraldehyde 
• 64-17-5 ethanol 
• 80914-25-6 3-(Acetylamino)capronsaeure-methylester 
• 27829-71-6 (Z)-ethyl hex-2-enoate 
• 80914-19-8 3-Acetylamino-2-hexensaeure-methylester 
• 134455-46-2 ethyl 3-(benzylamino)caproate 

Downstream Products

• 91298-66-7 (S)-2-aminopentanonic acid 
• 68889-61-2 3-Amino-hexanol 

Relevant academic research and scientific papers

GABA-uptake inhibitors: Construction of a general pharmacophore model and successful prediction of a new representative

A model for the pharmacophore of GABA-uptake inhibitors was established using published structure-activity data and molecular modeling. The model accounted for the activities of different classes of GABA-uptake inhibitors. Analogues of guvacine substituted at position 6 were synthesized in order to confirm the model. 6-(3,3-Diphenylpropyl)guvacine (30f), which fit well with the pharmacophore, had an in vitro IC50 of 0.1 μM. This value is as good as those of the best GABA-uptake inhibitors known today.

Thiocarbonyl Olefination, IV. - Preparation of β-Amino Acids from N-(Acetyl)thioamides; Total Synthesis of Iturinic Acid

A new method for the synthesis of β-amino acids is described whose key step consists in the regioselective thiocarbonyl olefination of N-(acetyl)thioamides with methyl (triphenylphosphoranylidene)acetate.By this procedure, a straightforward synthesis of iturinic acid has been carried out for the first time.