913002-98-9

Usage

Chemical class

1H-Indazole

Core structure

1H-Indazole

Substituent

4-bromo-1-(2,4-difluorophenyl)-6-methyl

Common uses

Medicinal chemistry and drug discovery, potential scaffold for new pharmaceutical compounds

Unique features

Valuable tool for researchers, potential therapeutic applications, may have applications in organic synthesis and chemical research.

Upstream product

• 88174-23-6 2,6-dibromo-4-methylbenzaldehyde 
• 40594-29-4 (2,4-difluorophenyl)hydrazinium chloride 

Downstream Products

• 913003-48-2 2-{[(1-(2,4-difluorophenyl)-6-methyl-1H-indazol-4-yl)amino]methyl}-1,1,1-trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-pentanol 

Relevant academic research and scientific papers

INDAZOLES AS GLUCOCORTICOID RECEPTOR LIGANDS

The present invention is directed to compounds of formula (I): wherein A1 represents 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl; X represents -C(R3)- or nitrogen; when X represents -C(R3)-, R2 represents hydrogen and R1 represents fluorine, R3 represents hydrogen or fluorine, when X represents -C(R3)- and R2 and R1 each represent hydrogen, R3 represents hydrogen, hydroxy, methoxy or fluorine, when X represents -C(R3)- and R2 represents hydroxy, methoxy, -CO2CH3 or -CO2CH2CH3, R1 and R3 each represent hydrogen, when X represents nitrogen, R1 and R2 each represent hydrogen; and Y represents H or methyl; and physiologically functional derivatives thereof, pharmaceutical compositions and formulations comprising the compounds, the use of the compounds for the manufacture of medicaments particularly for the treatment of inflammatory and/or allergic conditions and/or skin diseases, processes for the preparation of the compounds, and chemical intermediates in the processes for the manufacture of the compounds.