913003-48-2

Upstream product

• 88174-23-6 2,6-dibromo-4-methylbenzaldehyde 
• 40594-29-4 (2,4-difluorophenyl)hydrazinium chloride 
• 913003-02-8 1,1,1-trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-{[(phenylmethyl)amino]methyl}-2-pentanol 
• 271587-47-4 2-[2-(5-fluoro-2-methoxyphenyl)-2-methylpropyl]-2-(trifluoromethyl)oxirane 
• 913002-98-9 4-bromo-1-(2,4-difluorophenyl)-6-methyl-1H-indazole 
• 611230-88-7 racemic 2-(aminomethyl)-1,1,1-trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-pentanol 

Relevant academic research and scientific papers

INDAZOLES AS GLUCOCORTICOID RECEPTOR LIGANDS

The present invention is directed to compounds of formula (I): wherein A1 represents 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl; X represents -C(R3)- or nitrogen; when X represents -C(R3)-, R2 represents hydrogen and R1 represents fluorine, R3 represents hydrogen or fluorine, when X represents -C(R3)- and R2 and R1 each represent hydrogen, R3 represents hydrogen, hydroxy, methoxy or fluorine, when X represents -C(R3)- and R2 represents hydroxy, methoxy, -CO2CH3 or -CO2CH2CH3, R1 and R3 each represent hydrogen, when X represents nitrogen, R1 and R2 each represent hydrogen; and Y represents H or methyl; and physiologically functional derivatives thereof, pharmaceutical compositions and formulations comprising the compounds, the use of the compounds for the manufacture of medicaments particularly for the treatment of inflammatory and/or allergic conditions and/or skin diseases, processes for the preparation of the compounds, and chemical intermediates in the processes for the manufacture of the compounds.