91303-98-9Relevant academic research and scientific papers
Thromboxane synthase inhibitors. Synthesis and pharmacological activity of (R)-, (S)-, and (±)-2,2-dimethyl-6-[2-(1H-imidazol-1-yl)-1-[[(4 methoxyphenyl)-methoxy]methyl]ethoxy]hexanoic acids
Manley,Tuffin,Allanson,Buckle,Lad,Lai,Lunt,Porter,Wade
, p. 1812 - 1818 (2007/10/02)
A series of substituted ω-[2-(1H-imidazol-1-yl)ethoxy]alkanoic acid derivatives were synthesized and evaluated for their ability to inhibit thromboxane synthase both in vitro and in vivo. Compound 13 was identified as a potent and selective competitive in
Certain 1H-imidazol-1-yl-1-lower-alkanoic acid derivatives having anti-thrombotic activity
-
, (2008/06/13)
Compounds of the general formula STR1 and pharmaceutically acceptable salts thereof have antithrombotic activity. Het represents 1-[1H-imidazolyl], 1-N-morpholinyl or pyridyl. A representative compound is 6-[2-(1H-Imidazol-1-yl)-1-yl-1-[[(4-methoxyphenyl)methoxy]methyl]ethoxy]hexanoic acid.
