913059-30-0Relevant academic research and scientific papers
Discovery and Pharmacophore Studies of Novel Pyrazole-Based Anti-Melanoma Agents
Li, Qing-Shan,Lü, Xian-Hai,Yang, Yang,Ruan, Ban-Feng,Yao, Ri-Sheng,Liao, Chen-Zhong
, p. 116 - 132 (2015/10/19)
Due to the rising incidence and lack of effective treatments, malignant melanoma is the most dangerous form of skin cancer, so that new treatment strategies are urgently needed. Several recent developments indicate that the V600E mutant BRAF (BRAFV60
Microwave assisted synthesis of some novel 2-pyrazoline derivatives as possible antimicrobial agents
Chawla, Rakesh,Sahoo, Ujjwal,Arora, Anshu,Sharma, Prabodh Chander,Radhakrishnan, Vijayaraj
experimental part, p. 55 - 61 (2010/06/12)
Some new [3-(4-phenyl)-5-phenyl-4,5-dihydropyrazol-1-yl](pyridine-4-yl) methanones and 3-substituted phenyl-5-substituted phenyl-4,5-dihydro-pyrazole-1- carbothioamides have been synthesized employing microwave techniques and evaluated for antimicrobial activity. Substituted acetophenones (1) were reacted with appropriately substituted benzaldehydes (2) in the presence of ethanol to furnish substituted chalcones (3a-f). These chalcones were further treated with isonicotinic acid hydrazide (INH) to afford substituted [3-(4-phenyl)-5-phenyl- 4,5-dihydropyrazol-1-yl](pyridine-4-yl)methanones (4a-f). Reaction of these chalcones with thiosemicarbazide yielded substituted 3,5-diphenyl-4,5-dihydro- 1H-pyrazole-1-carbothioamides (5a-f). The structures of newly synthesized compounds (4a-f) and (5a-f) have been confirmed by suitable spectroscopic techniques such as IR and 1H NMR. All the compounds were screened for their antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa and for antifungal activity against Candida albicans and Aspergillus niger. The compounds exhibited moderate antibacterial and good antifungal activities. Compound 4b and 4d showed significant antifungal activity against A. niger and C. albicans, respectively.
Synthesis and biological evaluation of some novel 1, 3, 5-trisubstituted pyrazolines
Revanasiddappa,Rao, R Nagendra,Subrahmanyam,Satyanarayana
experimental part, p. 295 - 298 (2011/01/03)
A new series of chalcones (3a-j) were synthesized by condensation of simple aldehydes with substituted acetophenones in presence of alkali. The resulted chalcones upon cyclization in presence of glacial acetic acid with isoniazid (INH) will yields the title compounds (4a-j). The newly synthesized compounds were assigned on the basis of IR, 1H NMR, and Mass spectral data. All the final compounds were evaluated for their in vitro antimicrobial activity.
