91306-50-2

Upstream product

• 5707-04-0 Phenylselenyl chloride 
• 5337-93-9 4'-methylpropiophenone 

Downstream Products

• 116333-28-9 2-Phenylselanyl-1-p-tolyl-propan-1-ol 
• 116333-28-9 2-Phenylselanyl-1-p-tolyl-propan-1-ol 
• 25574-04-3 1-p-tolyl-1-propanol 
• 19832-78-1 1-(4-methylphenyl)prop-2-en-1-one 
• 5337-93-9 4'-methylpropiophenone 
• 129803-02-7 benzeneselenyl fluoride 
• 449141-99-5 N-[N'-(diphenylmethylene)-(S)-p-(2-ethyl-1,3-dioxolan-2-yl)-phenylalanyl]-(-)-10,2-bornane sultam 
• 449142-02-3 (S)-Boc-p-[2'-(phenylselenenyl)propanoyl]phenylalanine 
• 449142-03-4 (S)-Boc-p-(propenoyl)phenylalanine 
• 449142-01-2 (S)-Boc-p-(propanoylphenyl)alanine 
• 449141-98-4 2-(p-bromomethyl-phenyl)-2-ethyl-1,3-dioxolane 
• 449141-97-3 2-ethyl-2-tolyl-1,3-dioxolane 

Relevant academic research and scientific papers

Stereo- and Chemo-Selectivity in reduction of α-alkyl Aryl Ketones with Metal Hydrides

Metal hydride reduction of a variety of α-alkyl aryl ketones gives a mixture of threo- and erythro-β-aryl-β-hydroxyalkyl phenyl(or methyl)selenides by carbonyl reduction and 1-aryl-1-alkanol by the substitution of a phenyl(or methyl)seleno group with hydrogen.With all metal hydrides examined the formation of the threo-isomer always predominated.The addition of various metal chlorides in the reduction of various α-heteroatom (N, P, O, S)-substituted ketones.

Preparation of 2-Arylpropanoic Acids by Oxidative Aryl Migration in (β-Aryl-β-hydroxy)alkyl Phenyl Selenides

Oxidation of diastereomeric mixtures of 1-aryl-1-hydroxyprop-2-yl phenyl selenides, prepared either by phenylselenylation of propiophenones followed by reduction or by treatment of benzaldehyde with α-(phenylseleno)ethyl anion, with an excess of meta-chloroperbenzoic acid in methanol at 25 deg C for 24 h or at reflux for 2 h affords methyl 2-arylpropanoates almost quantitatively.Similar treatment in tetrahydrofuran at 25 deg C for 24 h results in a direct formation of 2-arylpropanoic acids in high yields.

New Preparative Method for 2-Arylpropanoic Acids by Oxidative Aryl Migration in Aryl α-Seleno- and Aryl α-Telluro-ethyl Ketones

Oxidation with m-chloroperbenzoic acid of the ethylene acetals of aryl α-phenylseleno- or aryl α-phenyltelluro-ethyl ketones prepared by treating the corresponding α-bromo compounds with diphenyl diselenide-sodium or diphenyl ditelluride-sodium, respectively, affords hydroxyethyl 2-arylpropanoates in moderate to good yields via aryl group migration.