91322-00-8

Basic information

• Product Name: 5-Amino-2,4,6-trichloropyrimidine
• Synonyms: 5-Amino-2,4,6-trichloropyrimidine;2,4,6-Trichloro-5-pyrimidinamine;2,4,6-Trichloro-pyrimidin-5-ylamine;2,4,6-TRICHLOROPYRIMIDIN-5-AMINE(WXC08712)
• CAS NO: 91322-00-8
• Molecular Formula: C₄H₂Cl₃N₃
• Molecular Weight: 198.43778
• Mol File: 91322-00-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 260℃
• Flash Point: 111℃
• Appearance: /
• Density: 1.740
• Vapor Pressure: 0.013mmHg at 25°C
• Refractive Index: 1.645
• PKA: -3.97±0.10(Predicted)
• CAS DataBase Reference: 5-Amino-2,4,6-trichloropyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-2,4,6-trichloropyrimidine(91322-00-8)
• EPA Substance Registry System: 5-Amino-2,4,6-trichloropyrimidine(91322-00-8)

Safety Data

• Hazardous Substances Data: 91322-00-8(Hazardous Substances Data)

Usage

General Description

5-Amino-2,4,6-trichloropyrimidine is a chemical compound with the molecular formula C4HCl3N4. It is a derivative of pyrimidine and contains three chlorine atoms and an amino group. 5-Amino-2,4,6-trichloropyrimidine is commonly used in the synthesis of pharmaceuticals and agrochemicals due to its versatile reactivity and biological activity. It can also be used as a building block in the production of various organic compounds. Additionally, 5-Amino-2,4,6-trichloropyrimidine has potential applications in the fields of medicine, agriculture, and material science, making it an important intermediate in chemical synthesis.

InChI:InChI=1/C4H2Cl3N3/c5-2-1(8)3(6)10-4(7)9-2/h8H2

Upstream product

• 4359-87-9 2,4,6-trichloro-5-nitropyrimidine 

Downstream Products

• 55583-59-0 2,5-diamino-4,6-dichloropyrimidine 
• 116856-56-5 3-(4-{2-[6-Amino-9-((1R,2S,3R,4S)-4-ethylcarbamoyl-2,3-dihydroxy-cyclopentyl)-9H-purin-2-ylamino]-ethyl}-phenyl)-propionic acid tert-butyl ester 

Relevant articles and documents

Synthesis of ticagrelor analogues belonging to 1,2,3-triazolo[4,5-d]pyrimidines and study of their antiplatelet and antibacterial activity

Based on the recent observation that the antiplatelet agent ticagrelor and one of its metabolite exert bactericidal activity against gram-positive bacteria, a series of 1,2,3-triazolo[4,5-d]pyrimidines structurally related to ticagrelor were synthesized and examined as putative antiplatelet and antibacterial agents. The aim was to assess the possibility of dissociating the two biological properties and to find novel 1,2,3-triazolo[4,5-d]pyrimidines expressing antiplatelet activity and devoid of in vitro antibacterial activity. The new compounds synthesized were known metabolites of ticagrelor as well as structurally simplified analogues. Some of them were found to express antiplatelet activity and to lose the antibacterial activity, supporting the view that the two activities were not necessarily linked.

HEXAHYDROOXAZINOPTERINE COMPOUNDS

The present invention provides mTOR inhibitors of the formula wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods of making the compounds and intermediates thereof; and methods of using the compounds.