913358-64-2

Basic information

• Product Name: C₃₆H₄₆ClN₅O₅
• Synonyms: C₃₆H₄₆ClN₅O₅
• CAS NO: 913358-64-2
• Molecular Weight: 664.245
• Mol File: 913358-64-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₆H₄₆ClN₅O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₆H₄₆ClN₅O₅(913358-64-2)
• EPA Substance Registry System: C₃₆H₄₆ClN₅O₅(913358-64-2)

Safety Data

• Hazardous Substances Data: 913358-64-2(Hazardous Substances Data)

Upstream product

• 913358-53-9 (R)-2-[4-acryloyl-3-(3-chloro-phenyl)-5-methyl-2-oxo-[1,4]diazepan-1-yl]-3-naphthalen-1-yl-propionamide 
• 75178-96-0 N-Boc-1,3-diaminopropane 

Downstream Products

• 913358-31-3 (R)-2-[4-[3-(3-amino-propylamino)-propionyl]-3-(3-chloro-phenyl)-5-methyl-2-oxo-[1,4]diazepan-1-yl]-3-naphthal-1-yl-propionamide hydrochloride 

Relevant articles and documents

PHARMACEUTICALLY ACTIVE DIAZEPANES

Leukocyte Function-Associated Antigen One (LFA-1) is a cell adhesion molecule selectively expressed on leukocytes, and plays a major role in the activation and trafficking of T lymphocytes in the tissue at sites of inflammation. In the last decade a large body of preclinical data has accumulated to establish the importance of LFA-1 as a biological target, 10 particularly in chronic, T-cell driven inflammatory conditions. The present invention provides pharmaceutically active 1,4-diazepan-2-ones of formula I useful for the treatment of conditions related to LFA-1 activity.