913370-08-8Relevant articles and documents
An efficient asymmetric synthesis of (S)-2-cyclohexyl-2-phenylglycolic acid, the acid segment of oxybutynin
Roy, Siddharth,Sharma, Anubha,Chattopadhyay, Nilmadhav,Chattopadhyay, Subrata
, p. 7067 - 7069 (2007/10/03)
An innovative and facile synthesis of the title compound has been developed starting from (R)-cyclohexylidene glyceraldehyde. The key step in the synthesis is a chiral template-driven Grignard addition with absolute diastereocontrol. The other attractive features are the operational simplicity and the use of inexpensive compounds/reagents.