913488-45-6Relevant academic research and scientific papers
One-pot synthesis of highly functionalizable 3-(phenylsulfonyl)-2,3-dihydro-4(1H)-quinolinones via a Cu-catalyzed aza-Michael addition/cyclization reaction
Kang, Seongil,Yoon, Hongju,Lee, Yunmi
, p. 1356 - 1358 (2016)
A straightforward and mild one-pot method used for the synthesis of 3-(phenylsulfonyl)-2,3-dihydro-4(1H)-quinolinones via a Cu-catalyzed aza-Michael addition/base-mediated cyclization reaction is described. Addition of a range of readily available 2-aminobenzoates to phenyl vinyl sulfone was catalyzed by 5 mol% of a Cu complex at ambient temperature, followed by cyclization with KOt-Bu at 0°C to afford new versatile 3-sulfonyl-substituted-2,3-dihydro-4(1H)-quinolinones in good yield (53-99%).
SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR PRODUCTION AND USE THEREOF
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, (2013/10/22)
The present invention relates to novel substituted methyl-amines, serotonin 5-HT6 receptor antagonists, to active components, pharmaceutical compositions, method for prophylaxis and treatment of CNS diseases and “molecular tools”, in which novel substituted methyl-amines represent compounds of the general formula 1 and their crystalline forms and pharmaceutically acceptable salts, wherein: W represents benzene, naphthalene, indolizine, quinoline or oxazole cycle; R1=H, F, Cl; R2 represents hydrogen, fluoro, methyl, phenyl, thienyl, furan-2-yl, pyridyl, piperazin-1-yl or 4-methylpiperazin-1-yl; R3 represents cyclopropyl or optionally substituted methyl; with the exception of the compounds in which W simultaneously represents oxazole cycle and R2=phenyl or pyridyl.
