91352-62-4Relevant academic research and scientific papers
Surprising role of aryl halides in nickel-catalyzed reductive aldol reactions
Chrovian, Christa C.,Montgomery, John
, p. 537 - 540 (2007)
A new nickel-catalyzed method for the reductive aldol addition of acrylates and aldehydes has been developed. An unexpected requirement for an aryl iodide additive was found in the process, and the effect was shown to be linked to an initiation step.
Rapid and stereochemically flexible synthesis of polypropionates: Super-silyl-governed aldol cascades
Brady, Patrick B.,Yamamoto, Hisashi
, p. 1942 - 1946 (2012/04/04)
Polypropionates made EZ: The E/Z geometry of tris(trimethylsilyl)silyl super silyl enol ethers derived from propionaldehyde controls diastereoselectivity in the aldehyde crossed-aldol reaction. These silyl enol ethers can participate in polyaldol cascade reactions, thus allowing the one-pot synthesis of four different dipropionate stereotetrads (see scheme), and polyketides bearing up to five contiguous stereocenters.
