10557-27-4

Basic information

• Product Name: 1-(4-methoxyphenyl)propane-1,2-dione
• Synonyms: 1-(4-methoxyphenyl)propane-1,2-dione;1--1,2-propandione
• CAS NO: 10557-27-4
• Molecular Formula: C₁₀H₁₀O₃
• Molecular Weight: 178.1846
• Mol File: 10557-27-4.mol
• Article Data: 26

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 1-(4-methoxyphenyl)propane-1,2-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxyphenyl)propane-1,2-dione(10557-27-4)
• EPA Substance Registry System: 1-(4-methoxyphenyl)propane-1,2-dione(10557-27-4)

Safety Data

• Hazardous Substances Data: 10557-27-4(Hazardous Substances Data)

Usage

General Description

1-(4-methoxyphenyl)propane-1,2-dione, also known as p-methoxypropiophenone, is a chemical compound with the molecular formula C10H12O2. It is a white solid at room temperature and is often used as a building block in organic synthesis. It is commonly used in the production of pharmaceuticals and fragrances, as well as in the manufacturing of other chemicals. 1-(4-methoxyphenyl)propane-1,2-dione is a ketone, and its structure consists of a propane chain with a methoxyphenyl group attached to the first carbon and a carbonyl group attached to the second carbon. It has a sweet, floral odor and is classified as a hazardous chemical, requiring proper handling and storage.

Upstream product

• 4180-23-8 E-1-(4'-methoxyphenyl)prop-1-ene 
• 104-46-1 anethole 
• 91352-62-4 1-(4-methoxyphenyl)-2-methylpropane-1,3-diol 
• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 
• 19513-80-5 2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)ethan-1-one 
• 92409-23-9 3-hydroxy-2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)propan-1-one 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 140455-39-6 2-(2,6-dimethoxyphenoxy)-1-(4-methoxyphenyl)ethan-1-one 
• 7448-86-4 1-(4-methoxyphenyl)prop-2-en-1-one 
• 1443215-59-5 3-(4-methoxyphenyl)-3-oxoprop-1-en-2-yl acetate 
• 58379-80-9 1-(toluene-4-sulfonyl)-ethyl isocyanide 
• 100-07-2 4-methoxy-benzoyl chloride 
• 122-84-9 4-methoxybenzyl methyl ketone 
• 100-66-3 methoxybenzene 

Downstream Products

• 120390-77-4 (R)-(-)-1-hydroxy-1-(4-methoxyphenyl)propan-2-one 
• 93379-07-8 (S)-(-)-2-hydroxy-1-(4-methoxyphenyl)-1-propan-1-one 
• 5344-83-2 2-(hydroxyimino)-1-(4-methoxyphenyl)propan-1-one 
• 96920-93-3 1,1-difluoro-1-(4-methoxyphenyl)propan-2-one 
• 17492-68-1 2-(4-methoxyphenyl)-3-methylquinoxaline 
• 42455-41-4 4-(4-methoxyphenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester 
• 1076-95-5 p-methoxyphenylglyoxal 
• 89201-22-9 3-acetyl-1-(4'-methoxyphenyl)-2-pentene-1,4-dione 

Relevant articles and documents

New push–pull chromophores. Synthesis of 2-[4-Aryl-3-cyano-5-hydroxy-5-methyl-1H-pyrrol-2(5H)-ylidene]malononitriles

2-Aminoprop-1-ene-1,1,3-tricarbonitrile (malononitrile dimer) reacted with 1-arylpropane-1,2-diones in ethanol in the presence of piperidine to give new donor–acceptor chromophores, 2-[4-aryl-3-cyano-5-hydroxy-5-methyl-1H-pyrrole-2(5H)-ylidene]malononitriles.

Palladium-Catalyzed Synthesis of 1,2-Diketones from Aryl Halides and Organoaluminum Reagents Using tert-Butyl Isocyanide as the CO Source

In this work, an interesting and practical procedure for the synthesis of 1,2-diketones from aryl halides and organoaluminum reagents has been developed. Employing tert-butyl isocyanide as the CO source and palladium as the catalyst, the desired 1,2-diketones were isolated in good to excellent yields with good functional group tolerance. Concerning the reaction partners, besides aryl halides, both alkyl- A nd arylaluminum reagents were all suitable substrates here.

Magnesium Aldimines Prepared by Addition of Organomagnesium Halides to 2,4,6-Trichlorophenyl Isocyanide: Synthesis of 1,2-Dicarbonyl Derivatives

The selective addition of organomagnesium reagents to 2,4,6-trichlorophenyl isocyanide leading to magnesiated aldimines is reported. These aldimines react with Weinreb amides, ketones, or carbonates to provide the corresponding carbonyl derivatives after acidic cleavage. This allows for an efficient synthesis of 1,2-dicarbonyl compounds and α-hydroxy ketones.