913558-45-9Relevant academic research and scientific papers
GPR109a agonists. Part 2: Pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a
Imbriglio, Jason E.,Chang, Sookhee,Liang, Rui,Raghavan, Subharekha,Schmidt, Darby,Smenton, Abby,Tria, Scott,Schrader, Thomas O.,Jung, Jae-Kyu,Esser, Craig,Holt, Tom G.,Wolff, Michael S.,Taggart, Andrew K.P.,Cheng, Kang,Carballo-Jane, Ester,Waters, M. Gerard,Tata, James R.,Colletti, Steven L.
, p. 4472 - 4474 (2010)
5-Alkyl and aryl-pyrazole-acids have been identified as a new class of selective, small-molecule, agonists of the human orphan G-protein-coupled receptor GPR109a, a high affinity receptor for the HDL-raising drug nicotinic acid.
NIACIN RECEPTOR AGONISTS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
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Page/Page column 38; 39, (2008/06/13)
The present invention encompasses compounds of Formula I: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating dyslipidemias. Pharmaceutical compositions and methods of use are also included.
