913567-04-1Relevant articles and documents
Non-acidic pyrazole EP1 receptor antagonists with in vivo analgesic efficacy
Hall, Adrian,Billinton, Andy,Brown, Susan H.,Clayton, Nicholas M.,Chowdhury, Anita,Giblin, Gerard M.P.,Goldsmith, Paul,Hayhow, Thomas G.,Hurst, David N.,Kilford, Ian R.,Naylor, Alan,Passingham, Barry,Winyard, Lisa
experimental part, p. 3392 - 3399 (2009/04/06)
Replacement of the carboxylic acid group in a series of previously described methylene-linked pyrazole EP1 receptor antagonists led to the discovery of amide, reversed amide and carbamate derivatives. Two compounds, 10a and 10b, were identified