913617-26-2

Upstream product

• 676345-33-8 (E)-Hex-2-enedioic acid 6-methyl ester 1-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl] ester 
• 913617-22-8 2-bromopentenylbenzyl ether 
• 913617-24-0 (1S,2R)-2-(4-Benzyloxy-1-methylene-butyl)-5-oxo-cyclopentanecarboxylic acid methyl ester 
• 74-88-4 methyl iodide 
• 100-39-0 benzyl bromide 
• 64180-78-5 4-bromopent-4-en-1-ol 

Downstream Products

• 99877-51-7 4-(3-hydroxy-2,3-dimethyl-cyclopentyl)-pent-4-ene-1-ol 
• 913617-28-4 (1R,2S,3R)-3-(4-Benzyloxy-1-methylene-butyl)-1,2-dimethyl-cyclopentanol 
• 913617-27-3 (2S,3R)-3-(4-Benzyloxy-1-methylene-butyl)-2-methyl-cyclopentanone 

Relevant academic research and scientific papers

Total synthesis of (-)-chokol A by an asymmetric domino Michael addition-Dieckmann cyclization

A convergent and asymmetric total synthesis of (-)-chokol A was accomplished in six steps starting from the α,β-unsaturated ester (E)-9 in an overall yield of 27% with an enantiomeric excess of 95%. The key step of this synthesis is the asymmetric tandem conjugate addition-Dieckmann cyclization of the higher-order cuprate 8 derived from vinyl bromide 7 with the α,β-unsaturated ester (E)-9. Georg Thieme Verlag Stuttgart.