913623-70-8

Upstream product

• 165047-24-5 2,4,5-trifluorobenzaldehyde 
• 1263312-50-0 (E)-3-(2,4,5-trifluorophenyl)acrylaldehyde 
• 882856-63-5 (E)-ethyl-3-(2, 4, 5-trifluorophenyl)acetate 
• 1286756-60-2 ((4R,5S)-5-nitro-4-(2, 4, 5-trifluorophenyl)cyclohex-1-enyl)(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4, 3-a]pyrazin-7(8H)-yl)methanone 
• 1286756-59-9 (1R,2S)-2',4',5'-trifluoro-2-nitro-1,2,3,6-tetrahydro-[1,1'-biphenyl]-4-carboxylic acid 
• 1286756-58-8 (4R,5S)-tert-butyl-5-nitro-4-(2,4,5-trifluorophenyl)cyclohex-1-enecarboxylate 
• 1286756-57-7 (4R,5R)-tert-butyl-5-nitro-4-(2,4,5-trifluorophenyl)cyclohex-1-enecarboxylate 
• 1286756-56-6 (R)-4-nitro-3-(2,4,5-trifluorophenyl)butanal 
• 956924-25-7 2-nitro-1-(2,4,5-trifluorophenyl)ethanol 
• 76-05-1 trifluoroacetic acid 
• 915100-66-2 (E)-1,2,4-trifluoro-5-(2-nitrovinyl)benzene 

Relevant academic research and scientific papers

One-pot high-yielding synthesis of the DPP4-selective inhibitor ABT-341 by a four-component coupling mediated by a diphenylprolinol silyl ether

A dream come true: ABT-341 was synthesized in high yield with excellent diastereo- and enantioselectivity in a one-pot process mediated by a diphenylprolinol silyl ether (see scheme; TMS=trimethylsilyl). Thus, an asymmetric Michael reaction, a domino Mich