913642-44-1

Basic information

• Product Name: N-tert-butoxycarbonyl-1-amino-4-phenyl-2-butanol
• Synonyms: N-tert-butoxycarbonyl-1-amino-4-phenyl-2-butanol
• CAS NO: 913642-44-1
• Molecular Weight: 265.353
• Mol File: 913642-44-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-tert-butoxycarbonyl-1-amino-4-phenyl-2-butanol(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-butoxycarbonyl-1-amino-4-phenyl-2-butanol(913642-44-1)
• EPA Substance Registry System: N-tert-butoxycarbonyl-1-amino-4-phenyl-2-butanol(913642-44-1)

Safety Data

• Hazardous Substances Data: 913642-44-1(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 768-56-9 4-Phenylbut-1-ene 
• 1126-76-7 1,2-Epoxy-4-phenylbutane 
• 141377-53-9 1-nitro-4-phenylbutan-2-ol 
• 117974-11-5 (D,L)-4-phenyl-2-hydroxy-1-butylamine 
• 124481-51-2 trans-5-(trimethylsiloxy)-5,6-dihydro-3-phenyl-6-(trimethylsiloxy)-4H-1,2-oxazine 

Downstream Products

• 943321-38-8 1,1-dimethylethyl [2-(1,3-dioxo-1 ,3-dihydro-2H-isoindol-2-yl)-4-phenylbutyl]carbamate 

Relevant articles and documents

1,2-Amino Alcohols via Cr/Photoredox Dual-Catalyzed Addition of α-Amino Carbanion Equivalents to Carbonyls

Herein, we report the synthesis of protected 1,2-amino alcohols starting from carbonyl compounds and α-silyl amines. The reaction is enabled by a Cr/photoredox dual catalytic system that allows the in situ generation of α-amino carbanion equivalents which act as nucleophiles. The unique nature of this reaction was demonstrated through the aminoalkylation of ketones and an acyl silane, classes of electrophiles that were previously unreactive toward addition of alkyl-Cr reagents. Overall, this reaction broadens the scope of Cr-mediated carbonyl alkylations and discloses an underexplored retrosynthetic strategy for the synthesis of 1,2-amino alcohols.

INHIBITORS OF AKT ACTIVITY

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INHIBITORS OF AKT ACTIVITY

Invented are novel 1 H-imidazo[4,5-c]pyridin-2-yl compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.