913702-34-8

Usage

Uses

Used in Pharmaceutical Synthesis:
(R)-1,3'-Bipyrrolidine dihydrochloride is used as a key intermediate in the synthesis of various pharmaceuticals and organic compounds. Its unique structure allows for the creation of new drugs with potential therapeutic benefits.
Used in Asymmetric Catalysis:
(R)-1,3'-Bipyrrolidine dihydrochloride is used as a ligand in asymmetric catalysis processes. Its chiral properties enable the selective formation of enantiomers, which is crucial in the production of enantiomerically pure compounds for pharmaceutical applications.
Used in Chiral Resolution:
(R)-1,3'-Bipyrrolidine dihydrochloride is utilized in chiral resolution processes, where it helps in separating enantiomers of chiral compounds. This is important for obtaining pure enantiomers, which often exhibit different biological activities.
Used in Medicinal Chemistry and Drug Discovery:
(R)-1,3'-Bipyrrolidine dihydrochloride has potential applications in the field of medicinal chemistry and drug discovery. Its unique molecular structure and properties make it a promising candidate for the development of new drugs and therapeutic agents.

Upstream product

• 900164-96-7 (R)-1'-benzyl-[1,3']bipyrrolidinyl 
• 913702-27-9 tert-butyl (R)-[1,3'-bipyrrolidine]-1'-carboxylate 
• 1215039-65-8 C₁₃H₂₄N₂O₂ 
• 859213-31-3 (S)-1-benzyl-3-(1-pyrrolidinyl)pyrrolidine 

Relevant academic research and scientific papers

C-3 NOVEL TRITERPENONE WITH C-28 AMIDE DERIVATIVES AS HIV INHIBITORS

The invention relates to C-3 novel triterpenone with C-28 amide derivatives, related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases (formula 1).

Chiral 3-aminopyrrolidines as a rigid diamino scaffold for organocatalysis and organometallic chemistry

Over 20 new and easily prepared diamines were screened for the asymmetric Morita-Baylis-Hillman reaction. Chiral non-racemic 3-(N,N-dimethylamino)-1- methylpyrrolidine was found to promote efficiently the reaction of methyl vinyl ketone and substituted benzaldehydes. Enantiomeric excesses up to 73% were reached with electron-deficient benzaldehyde derivatives. After a simple deprotonation, one of these diamines was transformed into a chiral mixed aggregate for the enantioselective synthesis of (R)-1-o-tolylethanol with 76% ee.

N-benzoyl- and N-benzylpyrrolidin-3-ylamines as histamine-3 antagonists

The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.

AMIDE DERIVATIVE AND MEDICINE

The present invention is directed to an amide derivative having excellent BCR-ABL tyrosine kinase inhibitory activity, or a salt thereof. The present invention provides an amide derivative represented by the following general formula [1]: (wherein R1 represents -CH2-R11, etc.; R2 represents alkyl, halogen, haloalkyl, etc.; R3 represents hydrogen, etc.; Het1 represents a group of the formula [6] as above, etc.; and Het2 represents pyrimidinyl, etc.), or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention is useful as a BCR-ABL tyrosine kinase inhibitor.