913715-19-2Relevant academic research and scientific papers
TRPV1 Antagonists
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Page/Page column 43, (2012/10/08)
Disclosed herein are compounds of formula (I) or pharmaceutically acceptable salts, solvates, or combinations thereof, wherein X1, X2, X3, X4, J, K, L, X5, X6, Rb, G2, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
Rhodium-catalyzed asymmetric allylic substitution with boronic acid nucleophiles
Menard, Frederic,Chapman, Timothy M.,Dockendorff, Chris,Lautens, Mark
, p. 4569 - 4572 (2007/10/03)
An enantio-, regio-, and diastereoselective rhodium(I)-catalyzed desymmetrization of a meso-cyclic allylic dicarbonate with organoboronic acid nucleophiles is described. The rhodium(I) catalyst formed in situ from [Rh(cod)OH]2 and Xyl-P-PHOS al
Concise synthesis of trans- and cis-3,4-disubstituted piperidines based on regio- and stereoselective allylation of cyclopentenyl esters
Igarashi, Junji,Ishiwata, Hiroyuki,Kobayashi, Yuichi
, p. 8065 - 8068 (2007/10/03)
3,4-Disubstituted piperidines were synthesized through anti S N2′ allylation of 4-substituted 2-cyclopentenyl esters with reagents based on RMgX and CuX, thus allowing equal access to both trans- and cis-isomers. As an application, the paroxeti
