91374-03-7Relevant academic research and scientific papers
Toward structurally novel and metabolically stable HIV-1 capsid-targeting small molecules
Casey, Mary C.,Du, Haijuan,Kankanala, Jayakanth,Kirby, Karen A.,Lalji Sahani, Rajkumar,Sarafianos, Stefan G.,Tedbury, Philip R.,Vernekar, Sanjeev Kumar V.,Wang, Lei,Wang, Zhengqiang,Xie, Jiashu,Zhang, Huanchun
, (2020)
HIV-1 capsid protein (CA) plays an important role in many steps of viral replication and represents an appealing antiviral target. Several CA-targeting small molecules of various chemotypes have been studied, but the peptidomimetic PF74 has drawn particul
The reactions of cyclization of thiosemicarbazide derivatives to 1,2,4-triazole or 1,3,4-thiadiazole system
Dobosz, Maria,Pitucha, Monika,Wujec, Monika
, p. 31 - 38 (2007/10/03)
In the reaction of hydrazide of formic, nicotinic and benzoic acid with isothiocyanates were obtained the respective thiosemicarbazide derivatives [I-XII]. Further cyclization with 2% NaOH solution led to formation of derivatives Δ2-1,2,4-triaz
ADDITION-CYCLIZATION REACTIONS OF ETHYL ISOTHIOCYANATOACETATE WITH CARBOXYLIC ACIDS HYDRAZIDES
Veverka, Miroslav,Marchalin, Miroslav
, p. 113 - 119 (2007/10/02)
Ethyl (3-substituted 5-thioxo-1,2,4-triazolin-4-yl)acetates were prepared by addition-cyclization reaction of ethyl isothiocyanatoacetate with carboxylic acid hydrazides in the presence of sodium ethoxide.Thermal cyclization of the adduct in dimethylformamide afforded 1-acetamido-2-thiohydantoin.The effect of substituents on the cyclization course and the thione-thiol tautomerism are discussed.
