91376-46-4

Upstream product

• 116003-84-0 (2S,3S)-(3-(2-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)ethyl)-2-oxiranyl)methan-1-ol 
• 2181-42-2 trimethylsulphonium iodide 
• 125975-53-3 (2S)-O-(tert-butyldiphenylsilyl)-1,2-epoxybutan-4-ol 

Downstream Products

• 1240380-55-5 (tert-butyl)({(3S)-3-[(4-methoxybenzyl)oxy]pent-4-en-1-yl}oxy)diphenylsilane 
• 317855-28-0 (3S)-3-((methoxyphenyl)methyl)oxy-5-hydroxy-1-pentene 
• 1251927-22-6 C₂₇H₄₂O₂Si₂ 

Relevant academic research and scientific papers

Total synthesis of Z-isomer of phomolide B

We have achieved the synthesis of Z-isomer of phomolide B during our investigation toward the effect of protecting group on the outcome of ring-closing metathesis reaction. The other key reactions involved are cis-selective partial hydrogenation, Sharples

Total synthesis of nonenolide

A novel synthetic route has been reported for the synthesis of nonenolide. The syntheses of fragments were initiated from commercially available and inexpensive starting materials. The synthesis involves key steps like Sharpless epoxidation, Jacobsen's re

Total synthesis of decarestrictine i and botryolide B via RCM protocol

A convergent stereoselective total synthesis of decarestrictine I (1) and botryolide B (1a) invoking a common synthetic strategy is reported. The key steps are: ring-closing metathesis of epoxy dienoic esters obtained through the Yamaguchi esterification

First total synthesis of achaetolide

The first total synthesis of achaetolide, a 10-membered macrolactone was achieved using Mitsunobu reaction and Grubbs ring-closing metathesis reaction as the key steps for ring construction. The desired stereo centres were generated by Jacobsen hydrolytic kinetic resolution, dihydroxylation and Sharpless asymmetric epoxidation reactions.

First stereoselective total synthesis of decarestrictine O via RCM protocol

A convergent first stereoselective total synthesis of decarestrictine O via RCM protocol starting from 1,3-propanediol and propylene oxide is reported.