913839-73-3

Basic information

• Product Name: (6-Trifluoromethyl-pyridin-3-yl)-acetic acid
• Synonyms: (6-Trifluoromethyl-pyridin-3-yl)-acetic acid;2-(6-(TrifluoroMethyl)pyridin-3-yl)acetic acid;3-Pyridineacetic acid, 6-(trifluoroMethyl)-;2-(Trifluoromethyl)pyridine-5-acetic acid
• CAS NO: 913839-73-3
• Molecular Formula: C₈H₆F₃NO₂
• Molecular Weight: 205.14
• Mol File: 913839-73-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: (6-Trifluoromethyl-pyridin-3-yl)-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (6-Trifluoromethyl-pyridin-3-yl)-acetic acid(913839-73-3)
• EPA Substance Registry System: (6-Trifluoromethyl-pyridin-3-yl)-acetic acid(913839-73-3)

Safety Data

• Hazardous Substances Data: 913839-73-3(Hazardous Substances Data)

Usage

General Description

(6-Trifluoromethyl-pyridin-3-yl)-acetic acid is a chemical compound with the molecular formula C8H6F3NO2. It is a derivative of pyridine, a six-membered ring heterocyclic compound containing nitrogen. The trifluoromethyl group attached to the pyridine ring introduces significant electron-withdrawing character to the molecule, which can have implications for its reactivity and biological activity. The acetic acid group at the 3-position of the pyridine ring also adds to its chemical properties. (6-Trifluoromethyl-pyridin-3-yl)-acetic acid may have potential applications in pharmaceuticals, agrochemicals, and materials science, and its study may contribute to the development of new drugs or materials with specific properties.

Upstream product

• 1257088-58-6 ethyl 2-cyano-2-[6-(trifluoromethyl)-3-pyridyl]acetate 
• 936841-73-5 5-fluoro-2-(trifluoromethyl)pyridine 
• 765298-04-2 2-(6-(trifluoromethyl)pyridin-3-yl)acetonitrile 
• 386704-04-7 6-(trifluoromethyl)pyridin-3-ylmethanol 

Downstream Products

• 917486-25-0 N'-(5-bromo-4-(4-chlorophenyl)pyridin-2-yl)-2-(6-(trifluoromethyl)pyridin-3-yl)acetohydrazide 
• 1201194-22-0 (3,4-dimethyl-phenyl)-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-amine 

Relevant articles and documents

COMPOUNDS USEFUL AS CSF1 MODULATORS

This invention relates to novel compounds and to pharmaceutical compositions comprising the novel compounds. More specifically, the invention relates to compounds useful as Colony Stimulating Factor 1 Receptor (cFMS) modulators (e.g. cFMS inhibitors). This invention also relates to processes for preparing the compounds, uses of the compounds in treatment and methods of treatment employing the compounds. Specifically, the invention relates to the use of the compounds for the treatment of cancer and autoimmune diseases.

4-(PYRIDIN-3-YL)-2-(PYRIDIN-2-YL)-1,2-DIHYDRO-3H-PYRAZOL-3-ONE DERIVATIVES AS SPECIFIC HIF-PROLYL-4-HYDROXYLASE INHIBITORS FOR TREATING CARDIOVASCULAR AND HAEMATOLOGICAL DISEASES

The object of the invention is to provide new compounds which can be used for the treatment of diseases, in particular cardiovascular and haematological diseases. The present invention describes compounds which act as specific HIF-prolyl-4-hydroxylase inhibitors and which, because of this specific in vivo action mechanism, induce HIF target genes, such as erythropoietin, and the thus produced biological processes, such as erythropoiesis, after parenteral or oral administration. The present invention relates to compounds having the general formula (I), in which A stands for CH or N, R1 stands for a substituent selected from the group formed by (C1-C6)-alkyl, trifluoromethyl, halogen, cyano, nitro, hydroxy, (C1-C6)-alkoxy, amino, (C1-C6)-alkoxycarbonyl, hydroxycarbonyl and C(=O)-NH-R4; R2 stands for a substituent selected from the group formed by halogen, cyano, nitro, (C1-C6)-alkyl, trifluoromethyl, hydroxy, (C1-C6)-alkoxy, trifluoromethoxy, amino, hydroxycarbonyl and C(=O)-NH-R8; m equals 0, 1 or 2; n equals 0, 1, 2 or 3, it being possible for these meanings to be the same or different when R1 or R2 occurs multiple times; and R3 stands for hydrogen, (C1-C6)-alkyl or (C3-C7)-cycloalkyl. The invention also relates to the salts, solvates, and salt solvates of these compounds.