765298-04-2

Usage

Uses

Used in Pharmaceutical Industry:
3-Pyridineacetonitrile, 6-(trifluoromethyl)is used as a key intermediate in the synthesis of various pharmaceuticals due to its unique structural features that can be further elaborated to produce a range of bioactive molecules. Its presence in the molecular structure can contribute to the modulation of drug properties, such as solubility, stability, and binding affinity to target proteins.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Pyridineacetonitrile, 6-(trifluoromethyl)is employed as a reagent in the development of new pesticides and herbicides. Its chemical properties allow for the creation of compounds with enhanced pesticidal activity and selectivity, which can lead to more effective and environmentally friendly crop protection solutions.
Used in Material Science:
3-Pyridineacetonitrile, 6-(trifluoromethyl)is utilized as a precursor in the development of new materials, such as polymers and coatings, that can benefit from the compound's chemical and physical properties. Its incorporation into these materials can lead to improved performance characteristics, including durability, resistance to environmental factors, and specific interactions with other molecules.
Used in Pest Control Products:
Due to its insecticidal properties, 3-Pyridineacetonitrile, 6-(trifluoromethyl)is used as an active ingredient in the formulation of pest control products. It can be incorporated into sprays, traps, or other delivery systems to effectively manage and control pest populations in agricultural and residential settings.
Used in Heterocyclic Compound Synthesis:
As a versatile building block, 3-Pyridineacetonitrile, 6-(trifluoromethyl)is used in the synthesis of a variety of heterocyclic compounds. These compounds are important in many areas of chemistry, including the development of new pharmaceuticals, agrochemicals, and other specialty chemicals, where they can exhibit a range of biological activities and functional properties.

InChI:InChI=1/C8H5F3N2/c9-8(10,11)7-2-1-6(3-4-12)5-13-7/h1-2,5H,3H2

Upstream product

• 773837-37-9 sodium cyanide 
• 386704-04-7 6-(trifluoromethyl)pyridin-3-ylmethanol 
• 624-28-2 2,5-dibromopyridine 
• 349-94-0 5-chloro-2-(trifluoromethyl)pyridine 
• 223463-13-6 2-iodo-5-bromopyridine 
• 386715-33-9 3-chloromethyl-6-(trifluoromethyl)pyridine 
• 936841-73-5 5-fluoro-2-(trifluoromethyl)pyridine 
• 436799-32-5 5-bromo-2(trifluoromethyl)pyridine 
• 1616257-35-2 methyl 2-cyano-2-(6-(trifluoromethyl)pyridin-3-yl)acetate 
• 221313-10-6 methyl 6-(trifluoromethyl)pyridine-3-carboxylate 
• 231291-22-8 6-trifluoromethylnicotinic acid 
• 1257088-58-6 ethyl 2-cyano-2-[6-(trifluoromethyl)-3-pyridyl]acetate 

Relevant academic research and scientific papers

Application of Vinamidinium Salt Chemistry for a Palladium Free Synthesis of Anti-Malarial MMV048: A bottom-Up Approach

MMV390048 (1) is a clinical compound under investigation for antimalarial activity. A new synthetic route was developed which couples two aromatic fragments while forming the central pyridine ring over two steps. This sequence takes advantage of raw materials used in the existing etoricoxib supply chain and eliminates the need for palladium catalysts, which were projected to be major cost-drivers.

NITROGEN-CONTAINING HETEROCYCLIC ALKENYL COMPOUND, ORGANIC SEMICONDUCTOR MATERIAL AND ORGANIC SEMICONDUCTOR DEVICE

PROBLEM TO BE SOLVED: To provide a compound that is high in charge transfer and atmosphere stability and is suitable for an organic semiconductor material, provide an organic semiconductor material comprising the compound, and provide an organic semiconductor element comprising the organic semiconductor material. SOLUTION: The present invention provides a compound represented by formula (1), specifically a compound represented by formula (2) (Ar1 is an unsaturated cyclic hydrocarbon group or the like; Ar2 is an unsaturated heterocyclic group containing nitrogen with an unshared electron pair, or the like; B is -CH=CH- or -C≡C-; X11-X13 independently represent C-R or N; at least one of X12 and X13 is N). SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2018,JPOandINPIT

COMPOUNDS USEFUL AS CSF1 MODULATORS

This invention relates to novel compounds and to pharmaceutical compositions comprising the novel compounds. More specifically, the invention relates to compounds useful as Colony Stimulating Factor 1 Receptor (cFMS) modulators (e.g. cFMS inhibitors). This invention also relates to processes for preparing the compounds, uses of the compounds in treatment and methods of treatment employing the compounds. Specifically, the invention relates to the use of the compounds for the treatment of cancer and autoimmune diseases.

INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS

The invention relates to indole carboxamide derivatives of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.

NOVEL TRPV3 MODULATORS

Disclosed herein are modulators of TRPV3 of formula (II): wherein G1, X1, X2, X3, X4, X5, G2, Ra, Rb, and u are as defined in the specification. Composition

NOVEL TRPV3 MODULATORS

Disclosed herein are modulators of TRPV3 of formula (II): wherein G1, X1, X2, X3, X4, X5, G2, Ra, Rb, and u are as defined in the specification. Composition

Efficient methods for the synthesis of arylacetonitriles

Various approaches to [2-fluoro-4-(trifluoromethyl)phenyl]acetonitrile were investigated. Two of these methods were selected and applied to a variety of electron-deficient substrates, thereby expanding the scopes of the procedures.

HETEROAROMATIC MONOAMIDES AS OREXININ RECEPTOR ANTAGONISTS

The present invention is concerned with novel sulfonamides of formula wherein R1, R2, R3, R4, R5, Ar, Ar1, Ar2, n, o and p are as described in the description and claims. The compounds are orexin receptor antagonists that may be useful in the treatment of disorders, in which orexin pathways are involved.