913849-17-9

Basic information

• Product Name: Ethyl 2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanoate
• Synonyms: Ethyl 2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanoate;Propanoic acid, 2-methyl-2-[[5-(trifluoromethyl)-2-pyridinyl]oxy]-, ethyl ester;2-METHYL-2-[[5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY]-PROPANOIC ACID ETHYL ESTER
• CAS NO: 913849-17-9
• Molecular Formula: C₁₂H₁₄F₃NO₃
• Molecular Weight: 277.24
• Product Categories: API intermediates
• Mol File: 913849-17-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 291.6°C at 760 mmHg
• Flash Point: 130.2°C
• Appearance: /
• Density: 1.225g/cm³
• Vapor Pressure: 0.00193mmHg at 25°C
• Refractive Index: 1.45
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Ethyl 2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanoate(913849-17-9)
• EPA Substance Registry System: Ethyl 2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanoate(913849-17-9)

Safety Data

• Hazardous Substances Data: 913849-17-9(Hazardous Substances Data)

Usage

General Description

Ethyl 2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanoate is a chemical compound with the formula C13H14F3NO3. It is a transparent, colorless liquid that is commonly used as a flavoring agent and fragrance in various consumer products. This chemical is also utilized in the production of pharmaceuticals, agrochemicals, and other industrial products. It is known for its fruity, sweet odor and is considered to be relatively stable under normal conditions. However, it is important to handle this chemical with caution as prolonged or excessive exposure may lead to adverse health effects.

InChI:InChI=1/C12H14F3NO3/c1-4-18-10(17)11(2,3)19-9-6-5-8(7-16-9)12(13,14)15/h5-7H,4H2,1-3H3

Upstream product

• 52334-81-3 2-chloro-5-trifluoromethylpyridine 
• 600-00-0 ethyl 2-bromoisobutyrate 
• 33252-63-0 2-hydroxy-5-(trifluoromethyl)pyridine 

Downstream Products

• 605680-62-4 2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanoic acid 
• 605681-37-6 2-ethoxy-5-trifluoromethylpyridine 
• 876365-72-9 3-{(1S,2S)-1-(4-chlorobenzyl)-2-[(2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanoyl)amino]propyl}benzamide 
• 876365-70-7 N-[(1Z)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylprop-1-en-1-yl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide 
• 701977-00-6 N-[(1R,2R)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide 
• 701977-09-5 taranabant 

Relevant articles and documents

SUBSTITUTED 4-(4-FLUORO-3-(PIPERAZINE-1- CARBONYL)BENZYL)PHTHALAZIN-1(2H)-ONE DERIVATIVES AS POLY (ADP-RIBOSE) POLYMERASE- 1 INHIBITORS

Disclosed are compounds of general formula (I), their stereoisomers, regioisomers, tautomeric forms and novel intermediates involved in their synthesis, their pharmaceutically acceptable salts. These compounds are suitable as Poly (ADP-ribose) polymerase- 1 inhibitors (PARP-1 inhibitors).

Discovery of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1- methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity

The discovery of novel acyclic amide cannabinoid-1 receptor inverse agonists is described. They are potent, selective, orally bioavailable, and active in rodent models of food intake and body weight reduction. A major focus of the optimization process was to increase in vivo efficacy and to reduce the potential for formation of reactive metabolites. These efforts led to the identification of compound 48 for development as a clinical candidate for the treatment of obesity.