91392-61-9Relevant academic research and scientific papers
Phthalazinone-Assisted C-H Amidation Using Dioxazolones under Rh(III) Catalysis
Jeoung, Daeun,Kim, Kunyoung,Han, Sang Hoon,Ghosh, Prithwish,Lee, Suk Hun,Kim, Saegun,An, Won,Kim, Hyung Sik,Mishra, Neeraj Kumar,Kim, In Su
, p. 7014 - 7023 (2020/07/07)
The preparation of phthalazinone derivatives is pivotal for their utilization as pharmaceutical agents and other entities. Herein, we report the phthalazinone-assisted carbon-nitrogen bond forming reaction using dioxazolones as robust amidation sources under Rh(III) catalysis. The broad functional group tolerance and complete site-selectivity are observed. Notably, a series of transformations of synthesized compounds into biologically relevant N-heterocycles demonstrates the applicability of the developed methodology.
One-step ring condensation of hydrazine derivatives and cyclic anhydrides
Katrusiak, Anna,Katrusiak, Andrzej
, p. 28 - 36 (2015/03/05)
Hydroxypyridazinone and pyrroledione rings condensation in the reactions of hydrazine hydrate with citraconic, 2,3-dimethylmaleic, succinic and cis-cyclohexanedicarboxylic anhydrides have been conducted in the HCl aqueous solution. The pyridazine-ring condensation yields products unexpected for these conditions. They have been identified by 1H/13C NMR and X-ray diffraction. The course of the reaction toward the five- and six-membered ring condensation strongly depends on methyl and other substituents in the anhydrides and in hydrazine. The obtained products indicate that the ring condensation is controlled by the molecular strains and steric hindrances between the substituents in anhydrides and pyridazinone products. The condensation of cyclic anhydrides with hydrazines has been reduced to one-step reaction and its yield significantly increased.
