91407-41-9

Usage

Uses

Used in Pharmaceutical Industry:
5-Fluoro-2-hydroxybenzonitrile is used as a key building block in the synthesis of various drugs and biologically active compounds. Its unique structure and functional groups make it a valuable component in the development of new pharmaceuticals with improved therapeutic properties.
Used in Organic Synthesis:
5-Fluoro-2-hydroxybenzonitrile is employed as a versatile intermediate in organic synthesis, allowing for the creation of a wide range of chemical compounds. Its reactivity and functional groups enable chemists to modify and incorporate it into various molecular structures, leading to the development of new and innovative compounds with diverse applications.
Used in Research and Development:
As a chemical compound with unique properties, 5-Fluoro-2-hydroxybenzonitrile is utilized in research and development efforts to explore its potential applications and understand its chemical behavior. This knowledge can contribute to the advancement of organic chemistry and the discovery of new compounds with beneficial properties.
Used in Drug Design and Optimization:
5-Fluoro-2-hydroxybenzonitrile is used as a starting material in drug design and optimization processes. Its presence in a molecular structure can influence the pharmacokinetics, pharmacodynamics, and overall efficacy of a drug candidate, making it an important component in the development of novel therapeutic agents.
Used in Chemical Education and Training:
Due to its unique properties and applications, 5-Fluoro-2-hydroxybenzonitrile serves as a valuable teaching tool in chemical education and training programs. It can be used to demonstrate various concepts in organic chemistry, such as synthesis, reactivity, and molecular structure, helping students and researchers to develop a deeper understanding of the subject matter.

Upstream product

• 221347-71-3 5-fluorobenzo[d]oxazole 
• 91407-40-8 5-fluoro-2-hydroxybenzaldehyde oxime 
• 945614-14-2 2-(benzyloxy)-5-fluorobenzonitrile 
• 64248-64-2 2,5-difluorobenzonitrile 
• 50-00-0 formaldehyd 
• 371-41-5 4-Fluorophenol 
• 189628-38-4 5-fluoro-2-methoxybenzonitrile 
• 347-54-6 5-fluoro-2-hydroxybenzaldehyde 

Downstream Products

• 756839-67-5 5-Fluoro-2-(4-methyl-5-nitro-pyridin-2-yloxy)-benzonitrile 
• 1085941-47-4 2-(2-cyano-4-fluorophenoxy)acetamide 
• 1578263-63-4 C₂₀H₁₆FN₃O₃ 
• 1268833-75-5 2-(5,6-dihydro-4H-1,3-oxazin-2-yl)-4-fluorophenol 
• 756839-57-3 5-Fluoro-2-(3-methyl-4-nitrophenoxy)-benzonitrile 
• 1085941-51-0 (R)-2-(1-amino-2-methylpropyl)-8-fluoro-3-((4-methylthiophen-2-yl)methyl)benzofuro[3,2-d]pyrimidin-4(3H)-one 

Relevant academic research and scientific papers

Thiocyanate radical mediated dehydration of aldoximes with visible light and air

We developed a new means of activating aldoximes by an in situ generated thiocyanate radical from ammonium thiocyanate and molecular oxygen at room temperature. With a catalytic amount of organic dye aizenuranine as the photocatalyst, the dehydration of aldoximes proceeds smoothly under visible light irradiation, providing a simple to handle, excellent functional group tolerance, and metal-free protocol for a wide range of nitriles.

Preparation method of fluorine substituted piperidine derivative

The invention discloses a preparation method of a fluorine substituted piperidine derivative of 4-((2-(aminomethyl)-4-fluoro-phenoxybenzyl) methyl)piperidine-1-tert-butyl formate. 5-fluoro-2-hydroxybenzaldehyde is used as a starting raw material to obtain

Preparation method of fluorine substituted piperidine derivative

The invention discloses a preparation method of a fluorine substituted piperidine derivative of 4-((2-(aminomethyl)-4-fluoro-phenoxybenzyl) methyl)piperidine-1-tert-butyl formate. 5-fluoro-2-hydroxybenzaldehyde is used as a starting raw material to obtain

A catalytic route to ampakines and their derivatives

A catalytic domino reaction that efficiently provides access to an important class of heterocycles, the ampakines, is reported. Our approach is based on the cobalt-catalyzed hydroformylation of dihydrooxazines and allows for the facile synthesis of the pharmaceutically interesting compound CX-614 and related substances.

HYDROXYQUINOXALINECARBOXAMIDE DERIVATIVE

The present invention provides a novel hydroxyquinoxaline carboxamide derivative that is useful for preventing and/or treating blood coagulation disorders. A compound represented by formula (i), or a pharmacologically acceptable salt thereof: wherein, each of R1 and R2 independently represents a group such as a hydrogen atom or a halogen atom; R3 represents a group such as a hydrogen atom; each of R4 and R5 independently represents a group such as a hydrogen atom, a halogen atom or a C1-4 alkyl group; each of R6 and R7 independently represents a hydrogen atom or a C1-4 alkyl group; X represents a group such as a C3-10 cycloalkyl group, C6-10 aryl group or a 5- to 10-membered heterocyclic group, which may be substituted with substituent(s) selected from substituent group α; Y represents a group such as -CO-, -O- or -NRa-, and Ra represents a group such as a hydrogen atom or a C1-4 alkyl group.

KINESIN INHIBITORS

This invention relates to the compounds of formula (I) shown below. Each variable in formula (I) is defined in the specification. These compounds can be used to treat a kinesin Eg5 protein-mediated disorder.

A one-pot synthesis of substituted salicylnitriles

Phenols were converted to salicylaldehydes with paraformaldehyde, MgCl2-Et3N in THF, and subsequent treatment with aqueous ammonia gave the corresponding imines which were oxidized with IBX to the desired salicylnitriles. The sequence of reactions was conveniently carried out as a one-pot procedure under mild conditions.

KINASE INHIBITORS AND METHODS OF USE THEREOF

The compound of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof are useful in the treatment and prevention of various disorders mediated by kinases.

NOVEL BENZOFURAN DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USES OF THESE

[From equivalent EP1710233A1] The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 is hydrogen or lower alkyl; R2 is lower alkyl, halo-lower alkyl, cycloalkyl, heterocycloalkyl, aryl, aralkyl, arylalkenyl, aryloxy-lower alkyl, heteroaryl, heteroaryl-lower alkyl, etc; R3, R4, R5 and R6 are each hydrogen, halogen, cyano, lower alkyl, halo-lower alkyl, lower alkoxy, hydroxy, aryl, etc; provided that at least one of R3, R4, R5 and R6 is other than hydrogen. Compound (I) of the present invention shows a potent adenosine A2A receptor antagonistic activity, and are useful for treating or preventing a disease mediated by adenosine A2A receptors such as motor function disorders, depression, anxiety disorders, cognitive function disorders, cerebral ischemia disorders, restless legs syndrome and the like.

AMINO-TETRAZOLES ANALOGUES AND METHODS OF USE

A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R 5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.