91407-49-7

Upstream product

• 91407-48-6 2-(chloromethyl)-4,5-dimethoxy-1-fluorobenzene 
• 143-33-9 sodium cyanide 
• 544-92-3 copper(I) cyanide 
• 773837-37-9 sodium cyanide 
• 398-62-9 4-fluoroveratrole 

Downstream Products

• 1439376-31-4 2-(4,5-diethoxy-2-fluorophenyl)acetonitrile 
• 125228-08-2 2-<3,4-bis(benzyloxy)-6-fluorobenzyl>imidazoline 
• 125227-99-8 4,5-bis(benzyloxy)-2-fluorobenzyl cyanide 
• 99424-76-7 2-(2-fluoro-4,5-dimethoxyphenyl)ethan-1-amine 
• 125228-10-6 2-(2-fluoro-4,5-dihydroxyphenyl)acetonitrile 

Relevant academic research and scientific papers

MODULATORS OF LIPID STORAGE

Disclosed are compounds of formulas I, II, and III: Formulas I, II, and III wherein R1-R19 and n are as described herein, or pharmaceutically acceptable salts thereof, or an enantiomer thereof or a conjugate thereof wherein the conju

Synthesis and α2-adrenoceptor effects of substituted catecholimidazoline and catecholimidazole analogues in human platelets

It is known that the steric requirements for the interactions of catecholamines and catecholimidazolines with α1- and α2-adrenoceptors are different. New analogues of desoxycatecholimidazoline (1), desoxycatecholimidazole (3), benzylic hydroxyl substituted imidazole (4), and the aromatic fluorine substitution analogues of 1 at the 2 (5), 5 (6), and 6 (7) positions, and a set of asymmetric 4-substituted catecholimidazolines, S-8 and R-8, were prepared and tested for interaction with α2-adrenoceptors in human platelets. With the exception of 3, all compounds were selective for α-adrenoceptor-mediated responses in human platelets. Introduction of a double bond in imidazoline 1 to give an imidazole 3 or the introduction of a benzylic hydroxyl group to 3, as in 4, reduced the inhibition of platelet aggregation with a rank order potency of 1 > 3 > 4. Fluorine atom substitution at the 2-, 5-, or 6-positions only slightly modified the inhibitory activity of 1. Each analogue (1, 3-7) produced α2-mediated inhibition of platelet adenylate cyclase and can be classified as a partial agonist. The inhibition potency of S-8 and R-8 against epinephrine-induced aggregatory responses were greatly different, and only R-8 and 4 were α2-agonists on human platelet function. Our studies provide further evidence for the differential interaction of catecholamines and catecholimidazolines in α1- and α2-adrenoceptor systems.

SYNTHESIS OF 2,3-DIMETHOXY-5-FLUORO- AND 4,5-DIMETHOXY-2-FLUORO-SUBSTITUTED PHENYLACETIC AND PHENYLACETOHYDROXAMIC ACIDS

Many-stage methods were developed for the synthesis of 2,3-dimethoxy-5-fluorophenylacetic acid from 3-methyl-4,5-dimethoxyaniline and 4,5-dimethoxy-2-fluorophenylacetic acid from 3,4-dimethoxyaniline.Methods were also developed for their conversion into t