914085-85-1

Basic information

• Product Name: (R)-3-hydroxy-3-(3'-methoxyphenyl)propanenitrile
• Synonyms: (R)-3-hydroxy-3-(3'-methoxyphenyl)propanenitrile
• CAS NO: 914085-85-1
• Molecular Weight: 177.203
• Mol File: 914085-85-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-3-hydroxy-3-(3'-methoxyphenyl)propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-hydroxy-3-(3'-methoxyphenyl)propanenitrile(914085-85-1)
• EPA Substance Registry System: (R)-3-hydroxy-3-(3'-methoxyphenyl)propanenitrile(914085-85-1)

Safety Data

• Hazardous Substances Data: 914085-85-1(Hazardous Substances Data)

Upstream product

• 591-31-1 3-methoxy-benzaldehyde 
• 75-05-8 acetonitrile 
• 5000-65-7 2-bromo-3'-methoxyacetophenone 
• 103205-23-8 3-hjydroxy-3-(3-methoxyphenyl)propanenitrile 

Relevant articles and documents

Direct Catalytic Asymmetric Addition of Alkylnitriles to Aldehydes with Designed Nickel–Carbene Complexes

A direct catalytic asymmetric addition of acetonitrile to aldehydes that realizes over 90 % ee is the ultimate challenge in alkylnitrile addition chemistry. Herein, we report achieving high enantioselectivity by the strategic use of a sterically demanding NiII pincer carbene complex, which afforded highly enantioenriched β-hydroxynitriles. This highly atom-economical process paves the way for exploiting inexpensive acetonitrile as a promising C2 building block in a practical synthetic toolbox for asymmetric catalysis.