91409-76-6Relevant academic research and scientific papers
Antiinflammatory activity of N-(2-benzoylphenyl)alanine derivatives
Walsh,Sleevi,Sancilio
, p. 1317 - 1321 (2007/10/02)
A series of N-(2-benzoylphenyl)alanine derivatives were synthesized and tested for antiinflammatory activity in the Evans blue-carrageenan induced pleural effusion assay. The target compounds were envisioned to bind to a receptor site on the cyclooxygenase enzyme by a mechanism first proposed by Appleton and Brown. Of the 21 compounds prepared, two were found to be one-tenth as potent as indomethacin in the pleurisy model and one compound was tested and found to be weakly active in the adjuvant arthritis model.
