4937-62-6

Basic information

• Product Name: 2-AMINO-4-METHYLBENZOPHENONE
• Synonyms: 2-AMINO-4-METHYLBENZOPHENONE;(2-amino-4-methyl-phenyl)-phenyl-methanone;(2-amino-4-methylphenyl)-phenylmethanone;(2-azanyl-4-methyl-phenyl)-phenyl-methanone
• CAS NO: 4937-62-6
• Molecular Formula: C₁₄H₁₃NO
• Molecular Weight: 211.26
• EINECS: 225-577-8
• Product Categories: C13 to C14;Carbonyl Compounds;Ketones
• Mol File: 4937-62-6.mol
• Article Data: 17

Chemical Properties

• Melting Point: 65-66 °C(lit.)
• Boiling Point: 407.1°C at 760 mmHg
• Flash Point: 200°C
• Appearance: /
• Density: 1.135g/cm³
• Vapor Pressure: 7.75E-07mmHg at 25°C
• Refractive Index: 1.616
• CAS DataBase Reference: 2-AMINO-4-METHYLBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-METHYLBENZOPHENONE(4937-62-6)
• EPA Substance Registry System: 2-AMINO-4-METHYLBENZOPHENONE(4937-62-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 4937-62-6(Hazardous Substances Data)

Usage

Uses

2-Amino-4-methylbenzophenone has been used as starting reagent in the synthesis of: 4-phenyl-7-methyl-2-(2′-pyridyl)quinoline and 4-phenyl-7-methyl-2-[2′-(6′-methyl)pyridyl]-quinolineN-tert-butyl-2-{3(R)-[3-(3-chlorophenyl)ureido]-8-methyl-2-oxo-5(R)-phenyl-1,3,4,5-tetrahydrobenz[b]azepin-1-yl}acetamide

InChI:InChI=1/C14H13NO/c1-10-7-8-12(13(15)9-10)14(16)11-5-3-2-4-6-11/h2-9H,15H2,1H3

Upstream product

• 100-47-0 benzonitrile 
• 108-44-1 1-amino-3-methylbenzene 
• 98-88-4 benzoyl chloride 
• 26830-96-6 5-methyl-2-cyanoaniline 
• 98-80-6 phenylboronic acid 
• 2305-36-4 4-methylanthranilic acid 
• 108-86-1 bromobenzene 
• 100-58-3 phenylmagnesium bromide 
• 52164-38-2 N-(2-benzoyl-5-methylphenyl)acetamide 
• 873-55-2 sodium benzenesulfonate 
• 941-55-9 4-toluenesulfonyl azide 
• 134-84-9 4-Methylbenzophenone 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 54879-92-4 6-methyl-2,3-diphenyl-1H-indole 

Downstream Products

• 3098-18-8 2-hydroxy-4-methylbenzophenone 
• 1705-89-1 3-methyl-9H-fluoren-9-one 
• 139436-94-5 1-(2'-amino-4'-methylphenyl)-1-phenylprop-2-en-1-ol 
• 149195-56-2 N-(2-Benzoyl-5-methyl-phenyl)-2,2,2-trifluoro-acetamide 
• 91409-75-5 N-(2-benzoyl-5-methylphenyl)alanine ethyl ester 
• 52164-37-1 2-Iod-4-methylbenzophenon 
• 411238-50-1 2-benzyl-5-methylaniline 
• 335305-91-4 2-benzoyl-5-methylphenyl radical 
• 177365-01-4 5-methyl-2-(1-phenylvinyl)aniline 
• 177365-02-5 N-{methoxy-[5-methyl-2-(1-phenyl-vinyl)-phenylcarbamoyl]-methyl}-benzamide 
• 161464-84-2 7-methyl-4-phenyl-3-(1-phenyl-1H-tetrazol-5-yl)quinoline 

Relevant articles and documents

Synthesis of 1-Amino-2,2,2-trifluoroalkylphosphonates from Alkene-Tethered Trifluoroacetimidoyl Chlorides

The reaction of alkene-tethered trifluoroacetimidoyl chlorides with trialkyl phosphites furnishes 1-amino-2,2,2-trifluoroalkylphosphonates. The products were generated in moderate to good yields, and the scalability of this process was showcased. Partial hydrolysis of the phosphonate moiety was achieved. The cyclization is proposed to occur via formation of an imidoyl phosphonate intermediate that becomes susceptible to nucleophilic attack at nitrogen through the strong electron-withdrawing groups at the imidoyl carbon.

Visible Light Induced Cyclization to Spirobi[indene] Skeletons from Functionalized Alkylidienecyclopropanes

In this paper, we revealed a metal-free and visible light photoinduced method for the rapid construction of spirobi[indene] skeletons, providing a simple and efficient way for easy access to spirobi[indene] scaffolds under mild conditions along with a broad substrate scope and good functional group tolerance.

Deoxygenative Arylation of Carboxylic Acids by Aryl Migration

An unprecedented deoxygenative arylation of aromatic carboxylic acids has been achieved, allowing the construction of an enhanced library of unsymmetrical diaryl ketones. The synergistic photoredox catalysis and phosphoranyl radical chemistry allows for precise cleavage of a stronger C?O bond and formation of a weaker C?C bond by 1,5-aryl migration under mild reaction conditions. This new protocol is independent of substrate redox-potential, electronic, and substituent effects. It affords a general and promising access to 60 examples of synthetically versatile o-amino and o-hydroxy diaryl ketones under redox-neutral conditions. Furthermore, it also brings one concise route to the total synthesis of quinolone alkaloid, (±)-yaequinolone A2, and a viridicatin derivative in satisfying yields.