91410-01-4Relevant academic research and scientific papers
Aluminum Complexes Bearing Bidentate Amido-Phosphine Ligands for Ring-Opening Polymerization of ?-Caprolactone: Steric Effect on Coordination Chemistry and Reactivity
Wei, Chuanzhi,Han, Binghao,Zheng, Dejuan,Zheng, Quande,Liu, Shaofeng,Li, Zhibo
, p. 3816 - 3823 (2019)
The aluminum complexes LAlMe2 (Al1-Al5: LH = 2,6-(R1)2-4-R2-C6H2NHCH2C6H4-2-PPh2; Al1, R1 = H, R2 = H; Al2, R1 = Me, R2 = H; Al3, R1 = iPr, R2 = H; Al4, R1 = Ph2CH, R2 = iPr; Al5, R1 = Cl, R2 = H) have been synthesized and characterized by elemental analysis and 1H, 13C, and 31P NMR. NMR analysis in solution reveals an interesting hemilabile coordination of the soft P donor. The molecular structures of Al2-Al4 were defined by X-ray diffraction studies, showing a distorted-tetrahedral geometry around the aluminum center in all structures. Careful comparison of these crystal structures suggested that different substituents on the ligands could lead to unignorable changed coordination environments around the Al center, thus affecting their catalytic properties. In the presence of BnOH, complexes Al1-Al5 efficiently catalyzed the ring-opening polymerization (ROP) of ?-caprolactone (?-CL) with high conversions in a controlled manner, and high molecular weights (Mn up to 118.6 kg mol-1) of polycaprolactones (PCLs) were readily prepared. Immortal polymerizations by Al4 having bulky Ph2CH groups were also studied with up to 20 equiv of alcohols and 2000 equiv of monomers, without sacrificing polymerization control.
[2-(Anilinomethyl)phenyl]diphenyl phosphine and {2-[(N-methylanilino)- methyl]phenyl}diphenylphosphine
Pretorius, Marie,Williams, D. Bradley G.,Roodt, Andreas,Muller, Alfred
, p. o384-o386 (2004)
The properties of two isomers C25H22NP and C 26H24NP along with Tolman angles were compared. It was observed that the two compounds were isomorphous, having individual molecules in the centrosymmetric space grou
Heteroditopic P,N ligands in gold(I) complexes: Synthesis, structure and cytotoxicity
Traut-Johnstone, Telisha,Kanyanda, Stonard,Kriel, Frederik H.,Viljoen, Tanya,Kotze, P.D. Riekert,Van Zyl, Werner E.,Coates, Judy,Rees, D. Jasper G.,Meyer, Mervin,Hewer, Raymond,Williams, D. Bradley G.
, p. 108 - 120 (2015/07/28)
New heteroditopic, bi- and multidentate imino- and aminophosphine ligands were synthesised and complexed to [AuCl(THT)] (THT = tetrahydrothiophene). X-ray crystallography confirmed Schiff base formation in three products, the successful reduction of the imino-group to the sp3-hybridised amine in several instances, and confirmed the formation of mono-gold(I) imino- and aminophosphine complexes for four Au-complexes. Cytotoxicity studies in cancerous and non-cancerous cell lines showed a marked increase in cytotoxicity upon ligand complexation to gold(I). These findings were supported by results from the 60-cell line fingerprint screen of the Developmental Therapeutics Programme of the National Institutes of Health for two promising compounds. The cytotoxicity of some of these ligands and gold(I)complexes is due to the induction of apoptosis. The ligands and gold(I)complexes demonstrated selective toxicity towards specific cell lines, with Jurkat T cells being more sensitive to the cytotoxic effects of these compounds, while the non-cancerous human cell line KMST6 proved more resistant when compared to the cancerous cell lines. Results from the NIH DTP 60 cell-line fingerprint screen support the observed enhancement of cytotoxicity upon gold(I) complexation. One gold(I)complex induced high levels of apoptosis at concentrations of 50 μM in all the cell lines screened in this study, while some of the other compounds selectively induced apoptosis in the cell lines. These results point towards the potential for selective toxicity to cancerous cells through the induction of apoptosis.
