91411-60-8

Basic information

• Product Name: Methanone, (5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)(2-chlorophenyl)-
• CAS NO: 91411-60-8
• Molecular Formula: C17H12Cl2N2O
• Molecular Weight: 331.201
• Mol File: 91411-60-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Methanone, (5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)(2-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)(2-chlorophenyl)-(91411-60-8)
• EPA Substance Registry System: Methanone, (5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)(2-chlorophenyl)-(91411-60-8)

Safety Data

• Hazardous Substances Data: 91411-60-8(Hazardous Substances Data)

Upstream product

• 91411-66-4 5-chloro-α-(2-chlorophenyl)-3-methyl-1-phenyl-1H-pyrazole-4-methanol 
• 1131-17-5 5-chloro-3-methyl-1-phenyl-1H-pyrazole 
• 609-65-4 o-chlorobenzoyl chloride 

Downstream Products

• 91411-55-1 (5-amino-3-methyl-1-phenyl-1H-pyrazol-4-yl)(2-chlorophenyl)methanone 
• 37703-93-8 4-(3-dimethylamino-propyl)-3-methyl-1-phenyl-1,4-dihydro-thiochromeno[2,3-c]pyrazol-4-ol 
• 37703-92-7 3-methyl-1-phenylthiochromeno[2,3-c]pyrazole-4(1H)-thione 
• 47480-63-7 dimethyl-[3-(3-methyl-1-phenyl-1H-thiochromeno[2,3-c]pyrazol-4-ylidene)-propyl]-amine 
• 37703-88-1 3-methyl-1-phenyl-1H-thiochromeno[2,3-c]pyrazol-4-one 

Relevant articles and documents

(1,3-Dialkyl-5-amino-1H-pyrazol-4-yl)arylmethanones. A series of novel central nervous system depressants

A series of novel (1,3-dialkyl-5-amino-1H-pyrazol-4-yl)arylmethanones was synthesized. Pharmacological evaluation of these compounds demonstrated central nervous system depressant activity, potential anticonvulsant properties, and a low order of acute toxicity. In addition, selected compounds showed potential antipsychotic effects. This report focuses on the synthesis and structure-activity relationships of these compounds. (5-Amino-1-ethyl-3-methyl-1H-pyrazol-4-yl)(2-chlorophenyl)methanone was the most active compound against pentylene-tetrazole-induced convulsions. (5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(3-chlorophenyl)methanone also has a favorable anticonvulsant depression ratio. (5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(3-trifluoromethylphenyl)methanone, (5-amino-1,3-dimethyl-1H-pyrazol-4-yl)(3-thienyl)methanone and (5-amino-3-ethyl-1-methyl-1H-pyrazol-4-yl)phenylmethanone are very potent depressants. (5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(2-thienyl)methanone possessed marked central depressant activity without anticonvulsant activity and without impairment of motor functioning. (5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(2-fluorophenyl)methanone has a behavioral profile suggestive of antipsychotic activity and gave a positive Ames test result.