1131-17-5

Basic information

• Product Name: 5-CHLORO-3-METHYL-1-PHENYLPYRAZOLE
• Synonyms: AKOS B029727;5-CHLORO-3-METHYL-1-PHENYLPYRAZOLE;BUTTPARK 48\06-20;5-chloro-3-methyl-1-phenyl-1H-pyrazole
• CAS NO: 1131-17-5
• Molecular Formula: C₁₀H₉ClN₂
• Molecular Weight: 192.64
• Mol File: 1131-17-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 114-115°C 4mm
• Flash Point: 114-115°C/4mm
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 0.00294mmHg at 25°C
• Refractive Index: 1.5794 (589.3 nm 20℃)
• PKA: -1.08±0.10(Predicted)
• CAS DataBase Reference: 5-CHLORO-3-METHYL-1-PHENYLPYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-3-METHYL-1-PHENYLPYRAZOLE(1131-17-5)
• EPA Substance Registry System: 5-CHLORO-3-METHYL-1-PHENYLPYRAZOLE(1131-17-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 23-24/25-36-26
• Hazardous Substances Data: 1131-17-5(Hazardous Substances Data)

Usage

General Description

5-Chloro-3-Methyl-1-Phenylpyrazole, also known as 926284-46-0, is a chemical compound with a molecular formula of C12H11ClN2. It's often used in the field of scientific research particularly, in experimental studies or as a building block in the synthesis of more complex chemical compounds. 5-CHLORO-3-METHYL-1-PHENYLPYRAZOLE belongs to the family of Pyrazoles. However, there is limited information regarding its toxicity, uses, environmental effects, and potential applications. Before handling or using this compound, proper protective measures, handling guidelines should be observed to ensure safety.

InChI:InChI=1/C10H9ClN2/c1-8-7-10(11)13(12-8)9-5-3-2-4-6-9/h2-7H,1H3

Upstream product

• 56159-67-2 (3-methyl-1-phenyl-1H-pyrazol-5-yl) benzoate 
• 1131-18-6 1-Phenyl-3-methyl-5-aminopyrazole 
• 60-80-0 antipyrine 
• 10026-13-8 phosphorus pentachloride 
• 10025-87-3 trichlorophosphate 
• 55774-20-4 1-benzyl-5-methyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one 
• 19735-89-8 3-methyl-1-phenylpyrazolin-5(4H)-one 
• 7719-12-2 phosphorus trichloride 
• 138853-66-4 (3-methyl-1-phenyl-1H-pyrazol-5-yl) acetate 
• 7647-01-0 hydrogenchloride 
• 89-25-8 edaravone 
• 5780-61-0 4,4-dichlorobut-3-en-2-one 
• 100-63-0 phenylhydrazine 
• 1140-38-1 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4?carboxylic acid 

Downstream Products

• 1020707-02-1 4-(5-chloro-3-methyl-pyrazol-1-yl)-aniline 
• 1344727-33-8 (3-methyl-1-phenyl-1H-pyrazol-5-yl)zinc pivalate 
• 401566-79-8 1-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine 
• 1610958-37-6 5-deuterio-3-methyl-1-phenyl-pyrazole 
• 1608125-55-8 3-methyl-5-(3-methyl-1-phenyl-1H-pyrazol-5-yloxy)-1-phenyl-1H-pyrazol-4-amine 
• 1608125-54-7 3-methyl-5-(3-methyl-1-phenyl-1H-pyrazol-5-yloxy)-4-nitro-1-phenyl-1H-pyrazole 
• 1447730-67-7 3-methyl-5-(3-methylbut-2-en-1-yl)-1-phenyl-1H-pyrazole 
• 1436429-82-1 diethyl 2-(2-(5-chloro-3-methyl-1H-pyrazol-1-yl)phenyl)malonate 
• 947-95-5 5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole 
• 1453841-39-8 5-(2,5-difluorophenyl)-3-methyl-1-phenyl-1H-pyrazole 
• 1394330-63-2 4-(5-chloro-3-methyl-1-phenylpyrazol-4-yl)-benzonitrile 
• 1394330-62-1 4-(5-chloro-3-methyl-1-phenylpyrazol-4-yl)-benzonitrile 
• 1394330-64-3 4-(5-chloro-3-methyl-1-phenylpyrazol-4-yl)-acetophenone 

Relevant articles and documents

Design, synthesis and anticandidal evaluation of indazole and pyrazole derivatives

Candidiasis, caused by yeasts of the genus Candida, is the second cause of superficial and mucosal infections and the fourth cause of bloodstream infections. Although some antifungal drugs to treat candidiasis are available, resistant strains to current therapies are emerging. Therefore, the search for new candicidal compounds is certainly a priority. In this regard, a series of indazole and pyrazole derivatives were designed in this work, employing bioisosteric replacement, homologa-tion, and molecular simplification as new anticandidal agents. Compounds were synthesized and evaluated against C. albicans, C. glabrata, and C. tropicalis strains. The series of 3-phenyl-1H-indazole moiety (10a–i) demonstrated to have the best broad anticandidal activity. Particularly, compound 10g, with N,N-diethylcarboxamide substituent, was the most active against C. albicans and both miconazole susceptible and resistant C. glabrata species. Therefore, the 3-phenyl-1H-indazole scaf-fold represents an opportunity for the development of new anticandidal agents with a new chemo-type.

Preparation method of 5-piperazinyl-3-methyl-1-phenylpyrazole

The invention discloses a preparation method of a Teneligliptin key intermediate 5-piperazinyl-3-methyl-1-phenylpyrazole, and belongs to the technical field of pharmaceutical manufacturing. Accordingto the preparation method disclosed by the invention, 3-

PYRAZOLE DERIVATIVES AND THEIR USES THEREOF

The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof; wherein U, R1, R2, R3 and Q are as defined herein. The disclosure also provides a method for treating or preventing a method for the prevention, treatment and/or alleviation of one or more autoimmune or alloimmune disease, pharmaceutical compositions and combination comprising a therapeutically effective amount of a compound, as defined herein.