91416-90-9

Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-5-iodo-3-methylpyrazine is used as a building block for the synthesis of various biologically active compounds. Its unique structure allows it to contribute to the development of new pharmaceuticals with potential therapeutic applications.
Used in Food Industry:
In the food industry, 2-Amino-5-iodo-3-methylpyrazine is used to enhance the flavor and aroma of food products. Its ability to impart specific taste and scent characteristics makes it a valuable ingredient in the creation of food additives and flavorings.
Used in Agricultural Industry:
2-Amino-5-iodo-3-methylpyrazine may possess pesticidal properties, making it a candidate for use in the development of new agrochemicals. Its potential to control pests and diseases in crops could lead to more effective and environmentally friendly agricultural solutions.

Upstream product

• 19838-08-5 amino-2 methyl-3 pyrazine 

Relevant academic research and scientific papers

INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS

Provided herein are compounds of formula (V) that bind to BF3 of an androgen receptor (AR), which can modulate the AR for the treatment of Kennedy's disease.

Synthesis of 5-Trifluoromethyl-Substituted (Z)- N, N -Dimethyl- N '-(pyrazin-2-yl)formimidamides from 2-Aminopyrazines, LiI/Selectfluor, FSO 2CF 2CO 2Me and DMF under Cu Catalysis

The synthesis of 5-trifluoromethyl-substituted (Z)-N,N-dimethyl-N'-(pyrazin-2-yl)formimidamides via the iodination of 2-aminopyrazines with Selectfluor/LiI followed by a domino trifluoromethylation with FSO2CF2CO2Me and a condensation with DMF in the presence of CuI is realized under mild conditions. This three-step method offers CF3-substituted (Z)-N,N-dimethyl-N'-(pyrazin-2-yl)formimidamides in yields of 55 70% and with high regioselectivities. LiI serves as an iodine source, whilst DMF functions as both a solvent and a condensation reagent. The regioselectivity of these trifluoromethylation reactions is strongly dependent upon the substituent pattern on the 2-aminopyrazines. A possible mechanism for this method is also discussed.

IODINATION OF SOME DIAZINES AND DIAZINE N-OXIDES

A number of monosubstituted pyrazines, pyrimidines, and their N-oxides having the electron-donating amino groups were successfully iodinated.Depending on the reaction conditions, the 3-substituted pyrazine 1-oxides having a bulky dialkylamino group yielded the 6-iodo and 2,6-diiodopyrazine N-oxide derivatives together with some deoxygenated products.The mechanism with supportive evidence was presented to account for these chemical transformations.