91419-94-2

Usage

Uses

Used in Analytical Chemistry:
Methyl-d3 Methanesulfonate is used as an internal standard for enhancing the accuracy and precision of quantitative analysis in mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. The incorporation of deuterium atoms provides a distinct mass difference, allowing for better separation and identification of target compounds in complex mixtures.
Used in Pharmaceutical Research:
In the pharmaceutical industry, Methyl-d3 Methanesulfonate serves as a valuable tool for studying drug metabolism and pharmacokinetics. Its deuterated nature enables researchers to differentiate between endogenous and administered compounds, facilitating the investigation of drug absorption, distribution, metabolism, and excretion (ADME) properties.
Used in Environmental Research:
Methyl-d3 Methanesulfonate is employed as a tracer compound in environmental studies, particularly for tracking the fate and transport of pollutants in various ecosystems. The deuterium labeling allows for the detection and quantification of trace amounts of contaminants, providing insights into their behavior and potential impacts on the environment.
Used in Chemical Synthesis:
In organic synthesis, Methyl-d3 Methanesulfonate can be utilized as a deuterated reagent or intermediate for the preparation of deuterated organic compounds. The incorporation of deuterium atoms can offer unique insights into reaction mechanisms and may lead to the development of novel synthetic routes and methodologies.

Upstream product

• 811-98-3 d⁽⁴⁾-methanol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 959786-30-2 d3-1-benzyloxy-4-(2-methoxy-ethyl)-benzene 
• 1079043-55-2 [2H]-Dextromethorphan 3,17-d6 
• 1079390-43-4 d3-7-methoxy-1-tetralone 

Relevant academic research and scientific papers

INDUSTRIAL PROCESS OF MONO-ALKYLATING A PIPERIDINE NITROGEN IN PIPERIDINE DERIVATIVES WITH DEUTERATED-ALKYL

The present invention relates to a method of mono-alkylating a piperidine nitrogen in a piperidine derivative with a deuterated lower-alkyl, which comprises protecting the piperidine nitrogen with an aralkyl protective group, lower-alkylating the piperidine nitrogen with a deuterated-lower-alkylating agent under neutral or basic condition, and then deprotecting the aralkyl protective group.

PREPARATION AND UTILITY OF SUBSTITUTED INDOLES

Disclosed herein are substituted indoles of Formula I, processes of preparation there of, pharmaceutical compositions thereof, and methods of their use there of.

HIGHLY SELECTIVE and LONG-ACTING PDE5 MODULATORS

Disclosed herein are substituted phosphodiesterase type 5 enzyme modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.

SUBSTITUTED NAPHTHALENES

Disclosed herein are substituted naphthalene-based melatonin (MT) receptor modulators and/or 5-HT receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.

DEUTERATED AMINOGLYCIDYL COMPOUNDS

Provided herein are substituted aminoglycidyl compounds of Formula (1), processes of preparation, and pharmaceutical compositions thereof and methods of their use for treating, preventing, or ameliorating one or more symptoms of a social anxiety disorder, an anxiety disorder, hyperthyroidism, tremor, glaucoma, hypertension, coronary artery bypass graft, chronic stable angina, atrial arrhythmia, migraine, bleeding esophageal varices, hypertrophic subaortic stenosis, heart failure, post-myocardial infarction, decreased left ventricular function after recent myocardial infarction, and/or any disorder ameliorated by beta adrenergic receptor modulators.