914220-72-7 Usage
Uses
Used in Organic Synthesis:
3-Bromo-2-chloromethyl-benzoic acid methyl ester is used as a building block in organic synthesis for the preparation of various pharmaceuticals and agrochemicals. Its unique structure and reactivity contribute to the development of diverse chemical compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-bromo-2-chloromethyl-benzoic acid methyl ester is used as an intermediate for the synthesis of drugs. Its specific functional groups and reactivity allow for the creation of new medicinal compounds with potential therapeutic applications.
Used in Agrochemical Industry:
3-Bromo-2-chloromethyl-benzoic acid methyl ester is also utilized in the agrochemical industry as a precursor for the development of pesticides and other agricultural chemicals. Its properties enable the production of effective compounds for crop protection and enhancement.
Used in Material Development:
In the field of material development, 3-bromo-2-chloromethyl-benzoic acid methyl ester is used for the creation of new materials. Its unique structure and reactivity make it a promising candidate for the development of advanced materials with specific properties for various applications.
Used in Chemical Process Development:
3-Bromo-2-chloromethyl-benzoic acid methyl ester is employed in the development of new chemical processes, both in industry and academia. Its potential for various applications makes it a valuable compound for exploring innovative and efficient methods in chemical synthesis and production.
Check Digit Verification of cas no
The CAS Registry Mumber 914220-72-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,4,2,2 and 0 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 914220-72:
(8*9)+(7*1)+(6*4)+(5*2)+(4*2)+(3*0)+(2*7)+(1*2)=137
137 % 10 = 7
So 914220-72-7 is a valid CAS Registry Number.
914220-72-7Relevant academic research and scientific papers
Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5- carbonitrile) analogues at monoamine transporters
Zhang, Peng,Cyriac, George,Kopajtic, Theresa,Zhao, Yongfang,Javitch, Jonathan A.,Katz, Jonathan L.,Newman, Amy Hauck
experimental part, p. 6112 - 6121 (2010/11/16)
(±)-Citalopram (1, 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1, 3-dihydroisobenzofuran-5-carbonitrile), and its eutomer, escitalopram (S-(+)-1) are selective serotonin reuptake inhibitors (SSRIs) that are used clinically to treat anxiety and depression. To further explore structure-activity relationships at the serotonin transporter (SERT), a series of (±)-4- and 5-substituted citalopram analogues were designed, synthesized, and evaluated for binding at the SERT, dopamine transporter (DAT) and norepinephrine transporter (NET) in native rodent tissue. Many of these analogues showed high SERT binding affinities (Ki = 1-40 nM) and selectivities over both NET and DAT. Selected enantiomeric pairs of analogues were synthesized and both retained enantioselectivity as with S- and R-1, wherein S > R at the SERT. In addition, the enantiomeric pairs of 1 and 5 were tested for binding at the homologous bacterial leucine transporter (LeuT), wherein low affinities and the absence of enantioselectivity suggested distinctive binding sites for these compounds at SERT as compared to LeuT. These novel ligands will provide molecular tools to elucidate drug-protein interactions at the SERT and to relate those to behavioral actions in vivo.
