91428-35-2Relevant academic research and scientific papers
Selective copper-promoted cross-coupling of aromatic amines with alkyl boronic acids
Larrosa, Marta,Guerrero, César,Rodríguez, Ramón,Cruces, Jacobo
supporting information; experimental part, p. 2101 - 2105 (2010/10/03)
A simple copper-promoted N-monoalkylation of anilines that utilizes alkyl boronic acids as the alkylating partner is presented. The reaction is carried out in refluxing dioxane, and it allows a number of structurally and electronically diverse anilines to be functionalized in a single step. A broad study was carried out to demonstrate the utility of this new methodology for the preparation of phenethylanilines.
